PAPER Vanlangenakker N, Vanden Berghe T, Vandenabeele P

Many stimuli pull the necrotic trigger, an overview.

Cell Death Differ. 2012 Jan;19(1):75-86. PubMed: 22075985

PAPER Kersse K, Verspurten J, Vanden Berghe T, Vandenabeele P

The death-fold superfamily of homotypic interaction motifs.

Trends Biochem Sci. 2011 Oct;36(10):541-52. PubMed: 21798745

PAPER Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J

Identification of RIP1 kinase as a specific cellular target of necrostatins.

Nat Chem Biol. 2008 May;4(5):313-21. PubMed: 18408713

PAPER Declercq W, Vanden Berghe T, Vandenabeele P

RIP kinases at the crossroads of cell death and survival.

Cell. 2009 Jul 23;138(2):229-32. PubMed: 19632174

PAPER Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Drory VE, Brown RH, Landers JE

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.

Nature. 2012 Aug 23;488(7412):499-503. PubMed: 22801503

PAPER Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

Nature. 2012 Jul 26;487(7408):443-8. PubMed: 22801498

PAPER Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5322-7. PubMed: 22421439

PAPER Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

Cell. 2012 Jan 20;148(1-2):213-27. PubMed: 22265413

Vicki Hoffmann

Eli Lilly
Indianapolis, United States

Yusheng Duan

China

PAPER Polishchuk VE

[Letter to the Editor concerning the article by K.G. Nikulin: "Hyperdiagnosis of chronic pneumonia and its social significance" (Terapevticheskiĭ Arkhiv, no. 6, 1977, pp. 55-57)].

Ter Arkh. 1978 Jan 1;50(2):127-8. PubMed: 644477

Novel Drug Knocks Aβ Off Synapses, Reduces Toxicity

RESEARCH NEWS 2012-07-20 Research News In AD therapy, it may be time for an alternative target to shine: the α7 nicotinic acetylcholine receptor. Earlier this week, scientists at the Alzheimer’s Association International Conference (AAIC), held 14-19 July 2012 in Vancouver, Canad

Amyloid Fibrils as Signaling Complexes? Role in Cell Death Pathway

RESEARCH NEWS 2012-07-20 Research News Amyloid deposits are often thought of as junk—toxic waste products clogging up cells. A paper in today’s Cell, however, suggests that at least one type of amyloid plays a crucial role in physiologic signaling. Researchers led by Hao Wu, a st

PAPER O'Dowd S, Curtin D, Waite AJ, Roberts K, Pender N, Reid V, O'connell M, Williams NM, Morris HR, Traynor BJ, Lynch T

C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism.

Mov Disord. 2012 Jul;27(8):1072-4. PubMed: 22807188

PAPER Zijlstra N, Blum C, Segers-Nolten IM, Claessens MM, Subramaniam V

Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching.

Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8821-4. PubMed: 22806998