Carmen Echavarri

Pamplona, Spain

Late- and Early Onset AD—Not So Distant at Genetic Level

RESEARCH NEWS 2012-02-14 Research News Mutations in amyloid precursor protein and presenilin can give rise to a late-onset, inherited version of Alzheimer’s disease, according to a paper in the February 1 PLoS One online. A consortium of researchers reports that rare variants in

Anthony Braun

University of Minnesota
Minneapolis, United States

Dave Morgan on ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

COMMENT The data presented in this paper show the most rapid removal of Aβ of any systemically applied therapy. They hold great promise for testing the amyloid hypothesis, and possibly for application in secondary prevention trials of asymptomatic patients where

Srinivasan Ramachandran

United States

Olivera Mitrasinovic on Love a Good Fight? Check Out Brouhaha Over Amyloid Imaging

COMMENT I disagree with Moghbel et al. It is well established that PIB has been a very useful diagnostic tool, and most likely other experimental compounds, including those seeking FDA approval, are, too. The specificity of binding to amyloid fibrils issue may be

Brian Trela

Flagler Hospital
St. Augustine, United States

Ermellina Murray

Eagleville, United States

Denise Levitch

United States

Ravi Anand

APC AG
Saint Moritz, Switzerland

PAPER Floris G, Borghero G, Cannas A, Di Stefano F, Costantino E, Murru MR, Brunetti M, Restagno G, Traynor BJ, Marrosu MG, Chiò A, Marrosu F

Frontotemporal dementia with psychosis, parkinsonism, visuo-spatial dysfunction, upper motor neuron involvement associated to expansion of C9ORF72: a peculiar phenotype?

J Neurol. 2012 Feb 10; PubMed: 22323211

PAPER Jiang J, Ganesh T, Du Y, Quan Y, Serrano G, Qui M, Speigel I, Rojas A, Lelutiu N, Dingledine R

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3149-54. PubMed: 22323596

PAPER Antonucci F, Alpár A, Kacza J, Caleo M, Verderio C, Giani A, Martens H, Chaudhry FA, Allegra M, Grosche J, Michalski D, Erck C, Hoffmann A, Harkany T, Matteoli M, Härtig W

Cracking down on inhibition: selective removal of GABAergic interneurons from hippocampal networks.

J Neurosci. 2012 Feb 8;32(6):1989-2001. PubMed: 22323713

PAPER Bandmann O, Cookson MR

Parkinson disease, cancer, and LRRK2: Causation or association?

Neurology. 2012 Feb 8; PubMed: 22323745

PAPER Zhou M, Ottenberg G, Sferrazza GF, Lasmézas CI

Highly neurotoxic monomeric α-helical prion protein.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3113-8. PubMed: 22323583