PAPER Jones N
SEARCH RESULTS
331209 RESULTS
Gael Barthet
French National Centre for Scientific ResearchBordeaux Area, France
George Perry on Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor
COMMENT Comment by George Perry, Rudy J. Castellani, and Mark A. Smith Failure of Amyloid-β-based Therapeutics: Is Amyloid the Culprit or the Savior? The failure of the amyloid-β-based therapeutic, semagacestat, to benefit patients suffering from Alzheimer diseas
PAPER Cochran E, Bacci B, Chen Y, Patton A, Gambetti P, Autilio-Gambetti L
Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease.
Am J Pathol. 1991 Sep;139(3):485-9. PubMed: 1716043Samir Kumar-Singh on Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
COMMENT This is a fascinating study on yet another TDP-43 transgenic mouse model driven by the mouse Thy1.2 promoter. The most notable outcome to catch my attention was that TDP-43 intranuclear inclusions in motor neurons did not colocalize with survival motor ne
Massimo Stefani on Microdissection and Microarrays: Analyzing Selective Cell Vulnerability
COMMENT The theme of selective cell vulnerability in neurodegenerative (but also in other amyloid) diseases is of the utmost importance to better understand the molecular basis of the pathological aggregate-cell interaction and its consequences. Most data so far
PAPER Xue WF, Hellewell AL, Gosal WS, Homans SW, Hewitt EW, Radford SE
Fibril fragmentation enhances amyloid cytotoxicity.
J Biol Chem. 2009 Dec 4;284(49):34272-82. PubMed: 19808677PAPER Cecchi C, Baglioni S, Fiorillo C, Pensalfini A, Liguri G, Nosi D, Rigacci S, Bucciantini M, Stefani M
Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates.
J Cell Sci. 2005 Aug 1;118(Pt 15):3459-70. PubMed: 16079288Jürgen Götz on The Plot Thickens: The Complicated Relationship of Tau and Aβ
COMMENT While Aβ and tau exert separate modes of toxicity, it is fascinating to see how more and more details are revealed about how these toxic entities interact to impair neuronal functions in dementias. The new data presented by Lennart Mucke’s team in Science