PAPER Attems J, Ittner A, Jellinger K, Nitsch RM, Maj M, Wagner L, Götz J, Heikenwalder M

Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.

J Neural Transm. 2011 May;118(5):737-45. PubMed: 21442354

PAPER Huang Y, Sun X, Hu G

An integrated genetics approach for identifying protein signal pathways of Alzheimer's disease.

Comput Methods Biomech Biomed Engin. 2011 Apr;14(4):371-8. PubMed: 21442495

PAPER Camicioli R, Sabino J, Gee M, Bouchard T, Fisher N, Hanstock C, Emery D, Martin WR

Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia.

Mov Disord. 2011 Jul;26(8):1443-50. PubMed: 21442661

PAPER Dhaenens CM, Tran H, Frandemiche ML, Carpentier C, Schraen-Maschke S, Sistiaga A, Goicoechea M, Eddarkaoui S, Van Brussels E, Obriot H, Labudeck A, Gevaert MH, Fernandez-Gomez F, Charlet-Berguerand N, Deramecourt V, Maurage CA, Buée L, de Munain AL, Sablonnière B, Caillet-Boudin ML, Sergeant N

Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing.

Biochim Biophys Acta. 2011 Jul;1812(7):732-42. PubMed: 21439371

PAPER Kosmidis S, Botella JA, Mandilaras K, Schneuwly S, Skoulakis EM, Rouault TA, Missirlis F

Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.

Neurobiol Dis. 2011 Jul;43(1):213-9. PubMed: 21440626

James Holstein

United States

Yubo Fan

United States

Wai-Tong Chien on Funding Woes: What’s Behind the Falling NIA Payline?

COMMENT As many researchers on aging, I was also surprisingly and painfully aware that the percentage of grant applications funded by the National Institute on Aging (NIA) has been much reduced in recent years. If only those grants scoring in the top three percen

Christian Lobsiger on Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.

COMMENT This new study by the lab of Jeffrey Macklis assesses if, beside the well-established degeneration of (lower) spinal cord motor neurons in the widely used mutant SOD1/G93A mouse line, there is also a loss of (upper) corticospinal motor neurons (CSMNs), as

Christian Lobsiger

Université Pierre et Marie Curie
PARIS cedex 13, France

PAPER Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ

A comparative study of Lrrk2 function in primary neuronal cultures.

Parkinsonism Relat Disord. 2010 Dec;16(10):650-5. PubMed: 20850369

PAPER Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.

J Neurosci. 2009 Nov 4;29(44):13971-80. PubMed: 19890007

Jesus Avila on The acetylation of tau inhibits its function and promotes pathological tau aggregation.

COMMENT From a single human gene, many different forms of tau protein could arise. Some of these forms come from alternative splicing of the nuclear RNA transcript, but other forms are the consequence of a post-translational modification—phosphorylation. Recently

Barcelona: What Lies Beyond Genomewide Association Studies?

CONFERENCE COVERAGE 2011-03-29 Conference Coverage The common late-onset forms of Alzheimer’s and Parkinson’s disease are now believed to involve substantial inherited risk. With the use of increasingly large genomewide association studies (GWAS), scientists are making headway dissecti

M. Paul Murphy on Barcelona: 10th AD/PD Conference Hosts a Shaken, Restive Field

COMMENT The AD/PD conference is a unique mixture of researchers in neurodegenerative disease from around the world. The science is always great, and so is the location. Looking forward to seeing everyone in Florence in 2013! mpmurp3 0