175125 RESULTS

TREM2 Buoys Microglial Disaster Relief Efforts in AD and Stroke

RESEARCH NEWS 2015-02-28 Research News When the going gets tough, microglia rely on TREM2 to get going. That was the common conclusion from two papers that investigated the role of the myeloid receptor in mouse models of Alzheimer’s disease and stroke. One study, led by Marco ...

Consortium Debuts Biggest Set of Human Epigenomes To Date

RESEARCH NEWS 2015-02-27 Research News A consortium of 258 researchers at 41 institutions, having completed 2,800 experiments and sequenced 150 billion DNA fragments over seven years, now presents the human epigenome. In the February 19 Nature, corresponding author Manolis Kellis ...

BACE Inhibitor Trial Put on Hold

RESEARCH NEWS 2015-02-27 Research News Vitae Pharmaceuticals announced on 26 February the temporary suspension of Phase I clinical testing of BI 1181181. This β-secretase (BACE) inhibitor is being developed by Boehringer Ingelheim and evaluated jointly with Vitae. Few details are ...

PAPER Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M

Integrative analysis of 111 reference human epigenomes.

Nature. 2015 Feb 19;518(7539):317-30. PubMed: 25693563

FDA Has Cleared New Cognitive Screening Tests

RESEARCH NEWS 2015-02-27 Research News The Food and Drug Administration recently cleared, meaning it deemed safe, two tests that may help doctors screen for cognitive decline. One is the so-called Cognision system from Neuronetrix, a company based in Louisville, Kentucky. It is ...

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