Jenny Gunnersen

The University of Melbourne
Parkville, Australia

Walter J. Schulz-Schaeffer on Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.

COMMENT This paper by Spinelli et al. fits well in my concept that presynaptic alpha-synuclein aggregates are pathophysiologically linked to the diseases PD, PDD, and DLB. It’s interesting to know that in-vivo multiphoton imaging may be able to monitor presynapti

Subhojit Roy on Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.

COMMENT These studies from Vivek Unni’s lab reiterate the importance of focusing on the synaptic accumulation and aggregation of α-synuclein, rather than somatic Lewy bodies. Specifically, they strengthen the hypothesis that small increments in α-synuclein are de

Alpha-Synuclein Types Congregate in Presynapse—Which Is the Bad One?

RESEARCH NEWS 2014-02-07 Research News Alpha-synuclein shape-shifts in synaptic terminals, according to a study that tracked the protein’s movements in the neurons of living mice. Published February 5 in The Journal of Neuroscience, the findings showed that while free α-synuclein

PAPER Rizo J, Südhof TC

The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?

Annu Rev Cell Dev Biol. 2012;28:279-308. PubMed: 23057743

PAPER Spinelli KJ, Taylor JK, Osterberg VR, Churchill MJ, Pollock E, Moore C, Meshul CK, Unni VK

Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.

J Neurosci. 2014 Feb 5;34(6):2037-50. PubMed: 24501346

Grants to Explore Boundaries Between Alzheimer’s and Parkinson’s

COMMUNITY NEWS 2014-02-07 Community News What do Alzheimer’s disease and Parkinson’s have in common, and what makes them unique? A new funding opportunity encourages researchers to re-examine the question. Biomarkers Across Neurodegenerative Diseases—BAND for short—will offer gran

Anna Tury

UC San Diego
La Jolla, United States

Aggressive Hypertension Treatment Accelerates Brain Atrophy in Diabetics

RESEARCH NEWS 2014-02-07 Research News Since diabetes and cardiovascular disease heighten the risk of cognitive decline, would treating the symptoms of these chronic diseases protect cognition? It’s a logical assumption, but the answer is no, according to a study in the February

Escort Service: A Cytoplasmic Role for TDP-43

RESEARCH NEWS 2014-02-07 Research News TDP-43 regulates mRNA metabolism in the nucleus and occurs in the cytoplasm mainly in the form of aggregates in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and other neurodegenerative disorders. Researchers

PAPER Frommelt P, Schnabel R, Kühne W, Nee LE, Polinsky RJ

Familial Alzheimer disease: a large, multigeneration German kindred.

Alzheimer Dis Assoc Disord. 1991;5(1):36-43. PubMed: 2025423

PAPER Merino JJ

Progranuline promotes repair in cortical neurons in vitro under excitotoxic conditions in vitro

Tissue Eng Part A; 2011 Jan (Submitted)

Edyta Truszkowska

Livia Civitelli

Linköping University

Simon Laws

Edith Cowan University
Australia