PAPER Demuro A, Parker I

Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.

J Neurosci. 2013 Feb 27;33(9):3824-33. PubMed: 23447594

PAPER Nadri H, Pirali-Hamedani M, Moradi A, Sakhteman A, Vahidi A, Sheibani V, Asadipour A, Hosseinzadeh N, Abdollahi M, Shafiee A, Foroumadi A

5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety.

Daru. 2013;21(1):15. PubMed: 23445881

PAPER Vos SJ, van Rossum IA, Verhey F, Knol DL, Soininen H, Wahlund LO, Hampel H, Tsolaki M, Minthon L, Frisoni GB, Froelich L, Nobili F, van der Flier W, Blennow K, Wolz R, Scheltens P, Visser PJ

Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI.

Neurology. 2013 Mar 19;80(12):1124-32. PubMed: 23446677

PAPER Burns JM, Swerdlow RH

Backwaters and rapids on the amyloid river.

Neurology. 2013 Mar 5;80(10):878-9. PubMed: 23446682

PAPER Jack CR, Wiste HJ, Lesnick TG, Weigand SD, Knopman DS, Vemuri P, Pankratz VS, Senjem ML, Gunter JL, Mielke MM, Lowe VJ, Boeve BF, Petersen RC

Brain β-amyloid load approaches a plateau.

Neurology. 2013 Mar 5;80(10):890-6. PubMed: 23446680

Alena Savonenko on Inducible APP Mice—Cognition Restored in Advanced Amyloidosis?

COMMENT The interpretation of preclinical findings for human disease must always be careful. It is intriguing that all measurable Aβ species, including soluble Aβ42, remained unchanged after transgene suppression. The deposited amyloid could be a reservoir that l

Alena Savonenko

Johns Hopkins Medicine
United States

Karen Hsiao Ashe on Inducible APP Mice—Cognition Restored in Advanced Amyloidosis?

COMMENT Regarding the conundrum of cognitive improvement despite lingering Aβ oligomers in the inducible APP mice, there are several issues to discuss. First, it may be premature to consider the immunoreactive smears to be Aβ oligomers. Neither 6E10 (Figs. 6A, B)

PAPER Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.

J Neurosci. 2013 Feb 27;33(9):3765-79. PubMed: 23447589

Lars-Olof Wahlund on Spinal Fluid Flush: Visualizing the Brain Drain With MRI

COMMENT It is a very interesting paper and proposes a new way for the brain to get rid of waste products. It can increase our knowledge in how Aβ is metabolized in the brain/body, something we need to know much more about to be able to fully understand the pathol

Lars-Olof Wahlund

Karolinska Institutet
Sweden

1996-1997 Scientific Advisory Board

Other Carl Cotman, Ph.D. Director, Institute for Brain Aging and Dementia University of California, Irvine Joseph Coyle Eben S. Draper Professor of Psychiatry and Neuroscience Harvard Medical School Peter Davies Albert Einstein College of Medicine, Scientific D

PAPER Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4027-32. PubMed: 23431133

PAPER Cummings JA, Mulkey RM, Nicoll RA, Malenka RC

Ca2+ signaling requirements for long-term depression in the hippocampus.

Neuron. 1996 Apr;16(4):825-33. PubMed: 8608000

PAPER Cho K, Aggleton JP, Brown MW, Bashir ZI

An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat.

J Physiol. 2001 Apr 15;532(Pt 2):459-66. PubMed: 11306664