PAPER Mårdh S, Nägga K, Samuelsson S

A longitudinal study of semantic memory impairment in patients with Alzheimer's disease.

Cortex. 2012 Feb 22; PubMed: 22445445

PAPER Dafnis I, Tzinia AK, Tsilibary EC, Zannis VI, Chroni A

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines.

Neuroscience. 2012 May 17;210:21-32. PubMed: 22445724

PAPER Castellani RJ, Moreira PI, Perry G, Zhu X

The role of iron as a mediator of oxidative stress in Alzheimer disease.

Biofactors. 2012 Mar-Apr;38(2):133-8. PubMed: 22447715

Zaixing Shi

Mailman School of Public Health
New York, United States

Elena Galea on Antioxidants No Help for Alzheimer’s, Biomarker Trial Says

COMMENT I believe that the 19 percent decrease in isoprostane, however small, is very relevant because this is the first time that any antioxidant treatment in AD has been proven to engage its target. However, if oxidative stress is a culprit in AD, then antioxid

Shelley Braham

Canada

PAPER Brotherton TE, Li Y, Cooper D, Gearing M, Julien JP, Rothstein JD, Boylan K, Glass JD

Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5505-10. PubMed: 22431618

C4F6 Targets Protein That Sinks Motor Neurons

RESEARCH NEWS 2012-03-27 Research News No, this isn’t about the board game "Battleship." C4F6 is an antibody to a mutant form of superoxide dismutase 1 (SOD1). In people with a rare form of amyotrophic lateral sclerosis, every cell produces mutant SOD1, but only certain