PAPER Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, Creager MA, Culebras A, Eckel RH, Hart RG, Hinchey JA, Howard VJ, Jauch EC, Levine SR, Meschia JF, Moore WS, Nixon JV, Pearson TA,

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.

Stroke. 2011 Feb;42(2):517-84. PubMed: 21127304

PAPER Nordström P, Nordström A, Eriksson M, Wahlund LO, Gustafson Y

Risk Factors in Late Adolescence for Young-Onset Dementia in Men: A Nationwide Cohort Study.

JAMA Intern Med. 2013 Aug 12; PubMed: 23939347

PAPER Levine DA

Young-Onset Dementia: Unanswered Questions and Unmet Needs.

JAMA Intern Med. 2013 Aug 12; PubMed: 23939189

PAPER Oslin D, Atkinson RM, Smith DM, Hendrie H

Alcohol related dementia: proposed clinical criteria.

Int J Geriatr Psychiatry. 1998 Apr;13(4):203-12. PubMed: 9646147

PAPER Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.

J Biol Chem. 2001 Oct 12;276(41):37743-6. PubMed: 11477090

Ana Griciuc on CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing.

COMMENT The article by Malik and colleagues offers new insights into the genetics of CD33, a gene that we first reported as a risk factor for Alzheimer’s disease (AD) in 2008 (Bertram et al., 2008). CD33 is a sialic acid-binding protein that we recently found to

PAPER Barcikowska M, Kwiecinski H, Liberski PP, Kowalski J, Brown P, Gajdusek DC

Creutzfeldt-Jakob disease with Alzheimer-type A beta-reactive amyloid plaques.

Histopathology. 1995 May;26(5):445-50. PubMed: 7657313

Sanjay Pimplikar on Suspected Non-Amyloid Pathology (SNAP)—Not an Open or Shut Case

COMMENT Time to SNAP out of it? Many of us have been consistently voicing the opinion that it will be helpful to widen our notion of pathogenesis of late-onset AD and also include non-amyloid agents/mechanisms as potential causative factors. If anything, findings

Wiep Scheper on Boosting Protein Translation PERKs Up Synapses in Alzheimer's Mice

COMMENT The exciting paper by Ma et al. contributes to the accumulating evidence that PERK is involved in neurodegeneration and is potentially a therapeutic target (reviewed in (1)). Our group reported previously the activation of the unfolded protein response (U

Rita Guerreiro on CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing.

COMMENT Even though the mechanism proposed by the authors is just a model (no experiments were done to actually demonstrate the involvement of sialic acids in the pathway), the identification of a potential functional polymorphism in linkage disequilibrium with a

Parkinsonism-linked Protein Binds Parkin and Pink1, Drives Mitophagy

RESEARCH NEWS 2013-08-22 Research News Growing evidence points to mitochondrial quality control as a key feature of familial Parkinson’s disease (PD) and related disorders. An August 11 Nature Neuroscience paper bolsters that notion. Researchers led by Helene Plun-Favreau at Univ

Protective Microglial Gene Variant Promotes Phagocytosis

RESEARCH NEWS 2013-08-22 Research News The immune system has recently seized the spotlight in Alzheimer’s research, with several genome-wide association studies (GWAS) linking the disease to genetic variation in microglia genes. However, it remains unclear how these genes influen

Do Alzheimer’s and Prion Diseases Share a Pathogenic Pathway?

RESEARCH NEWS 2013-08-22 Research News Dysregulated signaling through the cellular prion protein may exacerbate pathology in both Alzheimer’s and prion diseases, according to a report in the August 18 Nature Medicine. Researchers led by Benoit Schneider at INSERM, Paris, France,

Cognitive Function and Alcohol Major Predictors for Early Dementia

RESEARCH NEWS 2013-08-22 Research News The route to dementia can start early in life—as early as adolescence, according to a longitudinal study of Swedish men published in the August 12 JAMA Internal Medicine online. Peter Nordström and colleagues at Umeå University in Sweden plu

PAPER Hornberger M

Clinicopathologic differences among patients with behavioral variant frontotemporal dementia.

Neurology. 2013 Aug 20;81(8):775. PubMed: 23960196