PAPER Papaliagkas VT, Kimiskidis VK, Tsolaki MN, Anogianakis G

Cognitive event-related potentials: longitudinal changes in mild cognitive impairment.

Clin Neurophysiol. 2011 Jul;122(7):1322-6. PubMed: 21227748

PAPER Roe CM, Fagan AM, Williams MM, Ghoshal N, Aeschleman M, Grant EA, Marcus DS, Mintun MA, Holtzman DM, Morris JC

Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease.

Neurology. 2011 Feb 8;76(6):501-10. PubMed: 21228296

PAPER Petrella JR, Sheldon FC, Prince SE, Calhoun VD, Doraiswamy PM

Default mode network connectivity in stable vs progressive mild cognitive impairment.

Neurology. 2011 Feb 8;76(6):511-7. PubMed: 21228297

PAPER Van Dijk KR, Sperling RA

Defaulting on the default network: increased risk for dementia.

Neurology. 2011 Feb 8;76(6):498-500. PubMed: 21228298

PAPER Knopman DS

Tapping into the biology of Alzheimer disease.

Neurology. 2011 Feb 8;76(6):496-7. PubMed: 21228299

Raöul Franco

United States

Marco Racchi

University of Pavia
Pavia, Italy

Tony Wyss-Coray on Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening.

COMMENT This report by Kodadek’s group describes a novel approach in the search for disease-specific molecular biomarkers. The authors are screening patient sera to find specific endogenous immunoglobulins that would be characteristic of a given disease. The rati

David Holtzman on Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening.

COMMENT I think this new unbiased technology of looking for IgGs that bind to unique shapes on synthetic peptoids provides a valuable new methodology for discovery of IgGs that may be specific for certain disease states. The authors provide a good proof-of-concep

Wai-Tong Chien on Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver

COMMENT I am very sad to hear about death of Mark Smith. We have lost a great scientist in aging and health. As mentioned, Smith worked on a possible reactivation of the neuronal cell cycle as a mechanism in AD and the predominance of the amyloid hypothesis in Al

Virgil Muresan on Reimagining Alzheimer's disease--an age-based hypothesis.

COMMENT Karl Herrup got it right with his novel hypothesis on Alzheimer’s disease (AD). The two main brain pathological lesions associated with AD—the many forms of oligomeric Aβ and tau aggregates—most likely are not the cause, but the response to an injury. Acc

Mikael Gustavsson

Sweden

New Strategy Nets Biomarkers for AD, and More

RESEARCH NEWS 2011-01-14 Research News It met with little enthusiasm when originally proposed, and took more than three years to perfect, but a new strategy for detecting serum antibodies could have important ramifications for Alzheimer’s disease diagnostics. Like many groundbrea

PAPER Ferrari R, Kapogiannis D, Huey ED, Momeni P

FTD and ALS: a tale of two diseases.

Curr Alzheimer Res. 2011 May 1;8(3):273-94. PubMed: 21222600

PAPER Davies RR, Kipps CM

Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications.

Curr Alzheimer Res. 2011 May 1;8(3):261-5. PubMed: 21222601