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Daniele Juszkiewicz

Brazil

Maiara Oliveira

Anápolis, Brazil

PLB1-triple (hAPP/hTau/hPS1)

RESEARCH MODELS Summary The PLB1-triple model expresses low levels of mutant human APP, tau, and presenilin-1. The mice develop subtle age-related pathologies in the hippocampus and cortex, including accumulation of intraneuronal Aβ, a variety of oligomeric Aβ assemblies