Family History Affects Biomarkers, Science Tracks Their Course

RESEARCH NEWS 2011-10-21 Research News The profile of cerebrospinal fluid (CSF) amyloid-β (Aβ), tau, and other biomarkers associated with Alzheimer’s disease depends in part on a family history of AD, and the markers’ trajectory over time depends on the stage of disease. As laid

PAPER Liu CJ, Bosch X

Progranulin: A growth factor, a novel TNFR ligand and a drug target.

Pharmacol Ther. 2012 Jan;133(1):124-32. PubMed: 22008260

PAPER McMillan CT, Rascovsky K, Khella MC, Clark R, Grossman M

The neural basis for establishing a focal point in pure coordination games.

Soc Cogn Affect Neurosci. 2011 Oct 18; PubMed: 22009019

PAPER Chen KH, Chiu MJ, Cheng TW, Su JJ

Frontotemporal dementia and motor neuron disease: report of 3 cases in taiwan and literature review.

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PAPER Wood H

A hexanucleotide repeat expansion in C9ORF72 links amyotrophic lateral sclerosis and frontotemporal dementia.

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PAPER Stöckl M, Claessens MM, Subramaniam V

Kinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers.

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PAPER Corrochano S, Renna M, Carter S, Chrobot N, Kent R, Stewart M, Cooper J, Brown SD, Rubinsztein DC, Acevedo-Arozena A

α-Synuclein levels modulate Huntington's disease in mice.

Hum Mol Genet. 2012 Feb 1;21(3):485-94. PubMed: 22010050

PAPER Ghiani CA, Mattan NS, Nobuta H, Malvar JS, Boles J, Ross MG, Waschek JA, Carpenter EM, Fisher RS, de Vellis J

Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.

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PAPER Kim SR, Kareva T, Yarygina O, Kholodilov N, Burke RE

AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth.

Mol Ther. 2011 Oct 18; PubMed: 22008911

PAPER Zhang Q, Tanaka K, Sun P, Nakata M, Yamamoto R, Sakimura K, Matsui M, Kato N

Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients.

Neurobiol Dis. 2012 Jan;45(1):610-5. PubMed: 22008231

PAPER Srinivasan V, Cardinali DP, Srinivasan US, Kaur C, Brown GM, Spence DW, Hardeland R, Pandi-Perumal SR

Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection.

Ther Adv Neurol Disord. 2011 Sep;4(5):297-317. PubMed: 22010042

PAPER Levano K, Punia V, Raghunath M, Debata PR, Curcio GM, Mogha A, Purkayastha S, McCloskey D, Fata J, Banerjee P

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.

J Neurochem. 2012 Jan;120(2):302-313. PubMed: 22007859

PAPER Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Müller I, Schüller U, Kretzschmar H, Wolf E, Herms J

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly.

Hum Mol Genet. 2012 Feb 1;21(3):473-84. PubMed: 22010047

PAPER Aoki R, Li YR

α-synuclein promotes neuroprotection through NF-κB-mediated transcriptional regulation of protein kinase Cδ.

Sci Signal. 2011 Oct 18;4(195) PubMed: 22009151

PAPER Ormel L, Stensrud MJ, Bergersen LH, Gundersen V

VGLUT1 is localized in astrocytic processes in several brain regions.

Glia. 2012 Feb;60(2):229-38. PubMed: 22009457