Virgil Muresan on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.

COMMENT We would like to comment on a few issues raised by this paper and previous comments, starting with the now old observations from various groups, Gunnar Gouras’s in particular (1), that in the AD brain Aβ accumulates in a population of neurons in the vulne

PAPER Skovronsky DM, Doms RW, Lee VM

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture.

J Cell Biol. 1998 May 18;141(4):1031-9. PubMed: 9585420

Dennis Selkoe on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.

COMMENT In my view, the paper by Winton et al. supports the key point that one can prove the existence of intraneuronal Aβ only by using end-specific Aβ antibodies (i.e., to Aβ Ile42 or Val40, and, to a lesser extent, Asp1) that cannot recognize any APP epitopes

PAPER Gunstad J, Strain G, Devlin MJ, Wing R, Cohen RA, Paul RH, Crosby RD, Mitchell JE

Improved memory function 12 weeks after bariatric surgery.

Surg Obes Relat Dis. 2011 Jul-Aug;7(4):465-72. PubMed: 21145295

Gunnar Gouras on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.

COMMENT We agree with previous comments that Winton and colleagues provide interesting new evidence of APP accumulation and the possible lack of interaction between Aβ and tau in the triple-transgenic mouse. However, this paper is not enough to counter the hundre

Martin Ezeani

Brighton

PAPER Klingström B, Iwarsson K, Martinsson K

Acid-base measurements of arterial, venous and capillary blood in the dog.

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PAPER Fischbach GD, Berg DK, Cohen SA, Frank E

Enrichment of nerve--muscle synapses in spinal cord--muscle cultures and identification of relative peaks of ACh sensitivity at sites of transmitter release.

Cold Spring Harb Symp Quant Biol. 1976;40:347-57. PubMed: 7382

Zoe Allen

University of St Andrews

Research Brief: After Weight-Loss Surgery, AD-Related Proteins Drop

RESEARCH NEWS 2011-06-13 Research News Many epidemiological studies have pointed to a link between obesity and a higher risk of Alzheimer’s disease. Now, scientists led by Paresh Dandona at the State University of New York, Buffalo, report that people who undergo gastric bypass s

PAPER Ghani QP, Hollenberg M

Poly(adenosine dephosphate ribose) metabolism and regulation of myocardial cell growth by oxygen.

Biochem J. 1978 Feb 15;170(2):387-94. PubMed: 25065

PAPER Wang HH, Hsieh HL, Yang CM

Nitric oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix metalloproteinase-9.

J Cell Physiol. 2011 Sep;226(9):2244-56. PubMed: 21660948

PAPER Dranovsky A, Picchini AM, Moadel T, Sisti AC, Yamada A, Kimura S, Leonardo ED, Hen R

Experience dictates stem cell fate in the adult hippocampus.

Neuron. 2011 Jun 9;70(5):908-23. PubMed: 21658584

PAPER Furukawa Y, Kaneko K, Nukina N

Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties.

J Biol Chem. 2011 Aug 5;286(31):27236-46. PubMed: 21659525

PAPER Orsetti V, Pegoraro E, Cima V, D'Ascenzo C, Palmieri A, Querin G, Volpe M, Ermani M, Angelini C, Sorarù G

Genetic variation in KIFAP3 is associated with an upper motor neuron-predominant phenotype in amyotrophic lateral sclerosis.

Neurodegener Dis. 2011;8(6):491-5. PubMed: 21659726