RNA Deposits Confer Toxicity in C9ORF72 ALS

RESEARCH NEWS 2013-10-19 Research News Ever since the 2011 discovery that an expanded repeat in the C9ORF72 gene underlies cases of amyotrophic lateral sclerosis and frontotemporal dementia, researchers have wondered how the mutation causes disease. Recent work suggested that sma

PAPER Bickart KC, Brickhouse M, Negreira A, Sapolsky D, Barrett LF, Dickerson BC

Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale.

J Neurol Neurosurg Psychiatry. 2013 Oct 16; PubMed: 24133285

PAPER

ALS Untangled No. 21: Fecal transplants.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):482-5. PubMed: 23870000

PAPER Zhang J, Feng X, Wu J, Xu H, Li G, Zhu D, Yue Q, Liu H, Zhang Y, Sun D, Wang H, Sun J

Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β-amyloid through activation of SIRT1/Akt1 pathway.

Biofactors. 2013 Oct 17; PubMed: 24132831

PAPER Bohnen NI, Jahn K

Imaging: What can it tell us about parkinsonian gait?

Mov Disord. 2013 Sep 15;28(11):1492-500. PubMed: 24132837

PAPER Zamzow DR, Elias V, Shumaker M, Larson C, Magnusson KR

An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.

J Neurosci. 2013 Jul 24;33(30):12300-5. PubMed: 23884936

PAPER Yang S, Megill A, Ardiles AO, Ransom S, Tran T, Koh MT, Lee HK, Gallagher M, Kirkwood A

Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats.

J Neurosci. 2013 Jul 31;33(31):12670-8. PubMed: 23904603

PAPER Zhao YQ, Jordan IK, Lunyak VV

Epigenetics components of aging in the central nervous system.

Neurotherapeutics. 2013 Oct;10(4):647-63. PubMed: 24132650

PAPER Farina N, Young J, Tabet N, Rusted J

Prospective memory in Alzheimer-type dementia: Exploring prospective memory performance in an age-stratified sample.

J Clin Exp Neuropsychol. 2013 Nov;35(9):983-92. PubMed: 24131030

PAPER Tappen RM, Hain D

The Effect of In-Home Cognitive Training on Functional Performance of Individuals with Mild Cognitive Impairment and Early-Stage Alzheimer's Disease.

Res Gerontol Nurs. 2013 Oct 16;:1-11. PubMed: 24131045

PAPER Kyrtsos CR, Baras JS

STUDYING THE ROLE OF ApoE IN ALZHEIMER'S DISEASE PATHOGENESIS USING A SYSTEMS BIOLOGY MODEL.

J Bioinform Comput Biol. 2013 Oct;11(5):1342003. PubMed: 24131052

PAPER Szajer J, Murphy C

Education level predicts retrospective metamemory accuracy in healthy aging and Alzheimer's disease.

J Clin Exp Neuropsychol. 2013 Nov;35(9):971-82. PubMed: 24131064

PAPER Bleiholder C, Do TD, Wu C, Economou NJ, Bernstein SS, Buratto SK, Shea JE, Bowers MT

Ion mobility spectrometry reveals the mechanism of amyloid formation of Aβ(25-35) and its modulation by inhibitors at the molecular level: Epigallocatechin gallate and scyllo-inositol.

J Am Chem Soc. 2013 Nov 13;135(45):16926-37. PubMed: 24131107

PAPER Jonsson T, Stefansson K

TREM2 and neurodegenerative disease.

N Engl J Med. 2013 Oct 17;369(16):1568-9. PubMed: 24131183

PAPER Reitz C, Mayeux R, Alzheimer’s Disease Genetics Consortium

TREM2 and neurodegenerative disease.

N Engl J Med. 2013 Oct 17;369(16):1564-5. PubMed: 24131184