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Kloster Seeon meeting on BACE proteases in health and disease

CONFERENCE 2016-09-25 00:00:00-2016-09-27 00:00:00 Seeon-Seebruck, Bavaria, Germany 25 &#x2013 27 September 2016 This meeting is devoted entirely to the BACE proteases and their roles in health and disease. It will bring together internationally leading BACE researchers from both academia and industry ...

International Summit on Dementia and Intellectual Disability

CONFERENCE 2016-10-13 00:00:00-2016-10-14 00:00:00 Glasgow, Scotland 13 &#x2013 14 October 2016 The National Task Group on Intellectual Disability and Dementia Practices, the University of Illinois at Chicago, the University of the West of Scotland (UWS), and Alzheimer's Scotland are sponsoring ...

Michael Lardelli on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT It is fascinating to follow this debate between the teams of De Strooper/Chávez-Gutiérrez and Shen/Kelleher. The technical arguments presented by both teams in the discussion sections of their recent papers in Neuron are valuable information. However, ...

Wataru Araki on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT I am very interested in the debate on the pathological effects of PS1 inactive mutations. I rather agree that we should not underestimate the potential role of Aβ43 in the formation of Aβ aggregates. Aβ43 possibly acts as a seed to recruit other Aβ ...

Ray Kelleher on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT The present dispute concerns discrepancies between our finding that FAD-linked Psen1 knock-in (KI) mutations cause a loss of Aβ43 production in the adult mouse brain when mutant PS1 is expressed at normal levels and with the normal spatiotemporal pattern, ...

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