Heather Gray

United States

Rafal Smigrodzki

United States

Trent Nichols on Stockholm: Therapeutics Roundup—Some New, Some Not So Much

COMMENT A very important B study, but one lacking a methyl donor with the B6, folate, and B12. Unfortunately, the majority of therapeutic trials of the B vitamin ignore methyltetrahydrofolate reductase deficiency as a subgroup of Alzheimer's, which would be

Sanjay Pimplikar on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT This study provides elegant genetic evidence that reducing the BACE processing of APP protects against late-onset AD. The finding complements the long-standing observations that increased BACE processing (APPswe mutation or elevated BACE levels [1]) enhan

Yusheng Duan on Reversible mechanical unzipping of amyloid beta-fibrils.

COMMENT Good paper! 0 eeaduan

New Assays for Aβ Oligomers in CSF Claim Femtogram Sensitivity

CONFERENCE COVERAGE 2012-07-24 Conference Coverage The going hypothesis on amyloid-β forms states that oligomers are the most toxic species, and yet no one can robustly measure them in human CSF, where oligomers are rare clumps floating in a sea of monomer abundance. If researchers cou

Ethan Craig

Georgia Institute of Technology and Emory University
Atlanta, United States

Vahram (Harry) Haroutunian on Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.

COMMENT A recent longitudinal population-based study of older women by Mielke et al. showed that high serum ceramide levels were associated with an increased risk of all-cause dementia independent of age, blood glucose, and BMI. These findings are consistent with

No Pony in There: Bapi Fails Mild to Moderate ApoE4 Carriers

RESEARCH NEWS 2012-07-23 Research News Today, Pfizer conceded that results of the first of four Phase 3 trials of intravenous bapineuzumab, a monoclonal antibody against Aβ, failed to meet its co-primary endpoints in some 1,100 patients with mild to moderate Alzheimer’s disease w

Research Brief: Certain Serum Ceramides Increase Risk for AD

RESEARCH NEWS 2012-07-23 Research News Results of a nine-year longitudinal study indicate that women with the highest amounts of certain types of ceramide in their blood are more likely to develop Alzheimer’s disease. Researchers led by Michelle Mielke from the Mayo Clinic, Roche

Michael Ewers

Ludwig Maximilian University
Munich, Germany

PAPER Rutherford NJ, Dejesus-Hernandez M, Baker MC, Kryston TB, Brown PE, Lomen-Hoerth C, Boylan K, Wszolek ZK, Rademakers R

C9ORF72 hexanucleotide repeat expansions in patients with ALS from the Coriell Cell Repository.

Neurology. 2012 Jul 31;79(5):482-3. PubMed: 22815561

PAPER Svenningsson P, Westman E, Ballard C, Aarsland D

Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment.

Lancet Neurol. 2012 Aug;11(8):697-707. PubMed: 22814541

PAPER May VE, Nuber S, Marxreiter F, Riess O, Winner B, Winkler J

Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein.

Neuroscience. 2012 Oct 11;222:343-55. PubMed: 22814000

PAPER Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC

Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12556-61. PubMed: 22814375