MUTATIONS PSEN1 Exon 5 Point, Missense Coding Unknown. Unknown. I148W Parkinson's Disease Dementia: Unclear PathogenicityParkinson's Disease Dementia This mutation was identified in an individual with apparently sporadic Parkinson’s disease with dementia ...
MUTATIONS PSEN1 Exon 10 Point, Missense Coding Unknown. Unknown; imaging showed cerebral global atrophy. R352C Alzheimer's Disease: Unclear PathogenicityAlzheimer's Disease This mutation was reported in a Chinese Han family with a history of early-onset ...
RESEARCH NEWS 2015-01-25 Research News Amyloid plaques and tau tangles both characterize Alzheimer’s, but how does each drive the disease? A new study in the February 3 Cell Reports aims to disentangle their relative contributions to AD pathology. Researchers led by Frances ...
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RESEARCH NEWS 2015-01-23 Research News One strategy scientists are trying to slow the progression of Alzheimer’s is inhibiting the BACE1 enzyme that cleaves the amyloid precursor protein (APP). However, since BACE1 cuts a range of other substrates, side effects are a concern. One ...
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