Mouse Brain Circulatory System Knows No Bounds

RESEARCH NEWS 2013-06-09 Research News Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks. This surprising finding, published in the June 9 Nature Neuroscience online,

PAPER Nicholson AM, Finch NA, Wojtas A, Baker MC, Perkerson RB, Castanedes-Casey M, Rousseau L, Benussi L, Binetti G, Ghidoni R, Hsiung GY, Mackenzie IR, Finger E, Boeve BF, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Rademakers R

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.

J Neurochem. 2013 Jun 6; PubMed: 23742080

PAPER Elia AE, Petrucci S, Fasano A, Guidi M, Valbonesi S, Bernardini L, Consoli F, Ferraris A, Albanese A, Valente EM

Alpha-synuclein gene duplication: marked intrafamilial variability in two novel pedigrees.

Mov Disord. 2013 Jun;28(6):813-7. PubMed: 23744550

PAPER Han JH, Yu TH, Ryu HH, Jun MH, Ban BK, Jang DJ, Lee JA

ALS/FTLD-linked TDP-43 regulates neurite morphology and cell survival in differentiated neurons.

Exp Cell Res. 2013 Aug 1;319(13):1998-2005. PubMed: 23742895

PAPER Perfeito R, Cunha-Oliveira T, Rego AC

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.

Free Radic Biol Med. 2013 Sep;62:186-201. PubMed: 23743292

PAPER Khasnavis S, Ghosh A, Roy A, Pahan K

Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase.

J Biol Chem. 2013 Jul 19;288(29):20843-55. PubMed: 23744073

PAPER Müller T

Detoxification and antioxidative therapy for levodopa-induced neurodegeneration in Parkinson's disease.

Expert Rev Neurother. 2013 Jun;13(6):707-18. PubMed: 23739007

PAPER Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Böhm KJ, Winner B

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay.

J Biol Chem. 2013 Jul 26;288(30):21742-54. PubMed: 23744071

PAPER Foster JK, Albrecht MA, Savage G, Lautenschlager NT, Ellis KA, Maruff P, Szoeke C, Taddei K, Martins R, Masters CL, Ames D,

Lack of reliable evidence for a distinctive ε4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study.

Brain. 2013 Jul;136(Pt 7):2201-16. PubMed: 23737466

PAPER Cornejo F, von Bernhardi R

Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease.

Mediators Inflamm. 2013;2013:895651. PubMed: 23737655

PAPER Balsamo S, Willardson JM, Frederico Sd, Prestes J, Balsamo DC, Dahan da, Dos Santos-Neto L, Nobrega OT

Effectiveness of exercise on cognitive impairment and Alzheimer's disease.

Int J Gen Med. 2013;6:387-91. PubMed: 23737675

PAPER Yang ST, Lee JD, Chang TC, Huang CH, Wang JJ, Hsu WC, Chan HL, Wai YY, Li KY

Discrimination between Alzheimer's disease and mild cognitive impairment using SOM and PSO-SVM.

Comput Math Methods Med. 2013;2013:253670. PubMed: 23737859

PAPER Hong X, Bu L, Wang Y, Xu J, Wu J, Huang Y, Liu J, Suo H, Yang L, Shi Y, Lou Y, Sun Z, Zhu G, Behnisch T, Yu M, Jia J, Hai W, Meng H, Liang S, Huang F, Zou Y, Ge J

Increases in the risk of cognitive impairment and alterations of cerebral β-amyloid metabolism in mouse model of heart failure.

PLoS One. 2013;8(5):e63829. PubMed: 23737953

PAPER Chen JM, Huang CQ, Ai M, Kuang L

Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD).

Aging Clin Exp Res. 2013 May;25(2):153-7. PubMed: 23739900

PAPER Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

J Neurosci. 2013 Jun 5;33(23):9626-34. PubMed: 23739959