Željko Svedruzic on Déjà Vu? AD Patients Again Look Worse on γ-Secretase Inhibitor

COMMENT To understand why semagacestat and avagacestat failed, we need to understand the molecular properties of those compounds. Enzymatic mechanism studies offer insights into why those compounds can facilitate cognitive decline, and why current drug developmen

Who Will Progress to AD? Brain Microstructure Offers Clues

RESEARCH NEWS 2013-02-07 Research News Subtle alterations in the brain may help predict if people with mild cognitive impairment (MCI) will progress to Alzheimer’s disease (AD), according to a small study published in the January 30 Journal of Neuroscience. Using diffusion magnet

In Case You Wondered: Neurodegenerative Diseases Are Not Contagious

RESEARCH NEWS 2013-02-07 Research News Mounting evidence suggests that toxic proteins that cause Alzheimer's, Parkinson's, and other neurodegenerative diseases spread from neuron to neuron in a slow crawl through the brain. That news has sparked some concern among the m

PAPER Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, Bubacco L, de Bernard M

Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.

PLoS One. 2013;8(1):e55375. PubMed: 23383169

PAPER Russo I, Bubacco L, Greggio E

Exosomes-associated neurodegeneration and progression of Parkinson's disease.

Am J Neurodegener Dis. 2012;1(3):217-25. PubMed: 23383394

PAPER McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Tatzelt J, Appelhans D, Rogers MS

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc).

PLoS One. 2013;8(1):e55282. PubMed: 23383136

PAPER Salih BA

Prions. The mysterious infectious agents.

Neurosciences (Riyadh). 2004 Jan;9(1):11-8. PubMed: 23377297

PAPER Dexter DT, Jenner P

Parkinson disease: from pathology to molecular disease mechanisms.

Free Radic Biol Med. 2013 Feb 4; PubMed: 23380027

PAPER Verma A, Tandan R

RNA quality control and protein aggregates in amyotrophic lateral sclerosis: a review.

Muscle Nerve. 2013 Mar;47(3):330-8. PubMed: 23381726

PAPER Labandeira-Garcia JL, Rodriguez-Pallares J, Rodríguez-Perez AI, Garrido-Gil P, Villar-Cheda B, Valenzuela R, Guerra MJ

Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease.

Am J Neurodegener Dis. 2012;1(3):226-44. PubMed: 23383395

PAPER Zhou YF, Liao SS, Luo YY, Tang JG, Wang JL, Lei LF, Chi JW, Du J, Jiang H, Xia K, Tang BS, Shen L

SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.

PLoS One. 2013;8(1):e54214. PubMed: 23382880

PAPER Kolarcik CL, Bowser R

Retinoid signaling alterations in amyotrophic lateral sclerosis.

Am J Neurodegener Dis. 2012;1(2):130-45. PubMed: 23383387

PAPER Mizwicki MT, Fiala M, Magpantay L, Aziz N, Sayre J, Liu G, Siani A, Chan D, Martinez-Maza O, Chattopadhyay M, La Cava A

Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling.

Am J Neurodegener Dis. 2012;1(3):305-15. PubMed: 23383400

PAPER Yi J, Zhang L, Tang B, Han W, Zhou Y, Chen Z, Jia D, Jiang H

Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4.

PLoS One. 2013;8(1):e54792. PubMed: 23382971

PAPER Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Acta Neuropathol. 2013 Mar;125(3):413-23. PubMed: 23381195