Omi/HtrA2 (229926)

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Tim23 (32/Tim23)

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Hsp60 (24/HSP60)

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Torleif Hard on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT The toxic aggregates of the Aβ peptide that are thought to be responsible for at least the initial AD pathogenesis are either small soluble oligomers or larger, but still soluble, protofibrils that contain smaller aggregates as building blocks. A major pr

Brigita Urbanc on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT Protein Assembly Pathways Revealed? The question of assembly pathways is central to understanding the formation of protein structures associated with amyloid diseases. The latest research by Bleiholder et al. from the lab of Mike Bowers, recently publishe

David Teplow on Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation.

COMMENT Filling a Vacuum in Knowledge...With a Vacuum! Ion-Mobility Mass Spectrometry Provides Insight Into Amyloid Protein Assembly In an exciting new paper published in Nature Chemistry, Bleiholder et al. report that the technique of ion mobility-mass spectrome

Mitofilin

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Opa1 (V-20)

ANTIBODY polyclonal manufacturer Cat# sc-30572<br />Reference: <br /><a href="/papers/mitochondrial-g-secretase-participates-metabolism-mitochondria-associated-amyloid-precursor" target="_new">Pavlov PF, 2010</a> immunog

BAF170 (E-6)

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Chris Carter on Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

COMMENT Is this effect related to antibodies to β amyloid generated by inoculation? Such effects may be relevant to the proposed use of β amyloid antibodies in Alzheimer's disease, and to their toxicity (Ferrer et al., 2004). Immunization with tau in mice al

Chris Carter on Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.

COMMENT An online version of the full paper, with a NextBio highlighting service providing details of gene and scientific terms, is available at PolygenicPathways. 0 chris_car

Gordon Wilcock on Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)

COMMENT That subcortical nuclei other than the basal nucleus, e.g., the locus, may play a part in AD has long been suspected. Some colleagues and I reported on a small study of cell counts in different subcortical nuclei in autopsy-confirmed AD and control subjec

PAPER Wilcock GK, Esiri MM, Bowen DM, Hughes AO

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.

J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):842-9. PubMed: 3404192

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Tom20 (FL-145)

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