RESEARCH NEWS 2015-01-23 Research News One strategy scientists are trying to slow the progression of Alzheimer’s is inhibiting the BACE1 enzyme that cleaves the amyloid precursor protein (APP). However, since BACE1 cuts a range of other substrates, side effects are a concern. One ...
PAPER Isaji T, Kariya Y, Xu Q, Fukuda T, Taniguchi N, Gu J20816221
PAPER Zhao Y, Sato Y, Isaji T, Fukuda T, Matsumoto A, Miyoshi E, Gu J, Taniguchi N18384383
PAPER Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson JC, Marth JD, Varki N
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.Glycobiology. 2013 Mar;23(3):363-80. Epub 2012 Oct 31 PubMed: 23118208
PAPER Song Y, Aglipay JA, Bernstein JD, Goswami S, Stanley P
The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression.Cancer Res. 2010 Apr 15;70(8):3361-71. PubMed: 20395209
PAPER Nicoll RA, Kauer JA, Malenka RC2856092
PAPER Taniguchi N, Korekane H
Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics.BMB Rep. 2011 Dec;44(12):772-81. PubMed: 22189679
Riqiang Yan on An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
COMMENT This study described a novel observation that BACE1 stability can be regulated through bisecting N-acetylglucosamine. The authors showed that BACE1 normally undergoes bisecting N-acetylglucosamine by glycosyltransferase GnT-III (encoded by the MGAT3 gene) ...
Soraia Barao, Bart De Strooper on An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
COMMENT BACE1 stands as a very attractive therapeutic target for AD. However, with the identification of physiologically relevant BACE1 substrates, one should be aware that a complete block of BACE1 activity may lead to unintended side effects similar to what was ...
RESEARCH NEWS 2015-01-23 Research News Early on in amyotrophic lateral sclerosis motor, neurons fire like machine guns, but then they run out of ammo and go silent, according to a paper in the January 12 Nature Communications. Researchers from the University of St. Andrews in ...
PAPER Quinlan KA, Schuster JE, Fu R, Siddique T, Heckman CJ
Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.J Physiol. 2011 May 1;589(Pt 9):2245-60. Epub 2011 Feb 28 PubMed: 21486770
Shi-Yan Ng on Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
COMMENT I think that this is an exciting paper that reconciles the ALS motor neuron hyperexcitability/hypoexcitability dilemma. First, the current study reinforces that hyperexcitability is an intrinsic property of ALS motor neurons. More importantly, this ...
University of TorontoToronto, Canada
Nothwestern University Feinberg School of MedicineChicago, United States
Boston UniversityBoston, United States
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