PAPER Pandey RD, Gupta PP, Jha D, Kumar S

Role of statins in Alzheimer's disease: a retrospective meta-analysis for commonly investigated clinical parameters in RCTs.

Int J Neurosci. 2013 Apr 9; PubMed: 23438287

PAPER Banerjee S, Hellier J, Romeo R, Dewey M, Knapp M, Ballard C, Baldwin R, Bentham P, Fox C, Holmes C, Katona C, Lawton C, Lindesay J, Livingston G, McCrae N, Moniz-Cook E, Murray J, Nurock S, Orrell M, O'brien J, Poppe M, Thomas A, Walwyn R, Wilson K, Burns A

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

Health Technol Assess. 2013 Feb;17(7):1-166. PubMed: 23438937

PAPER Li X, Li TQ, Andreasen N, Wiberg MK, Westman E, Wahlund LO

Ratio of Aβ42/P-tau181p in CSF is associated with aberrant default mode network in AD.

Sci Rep. 2013;3:1339. PubMed: 23439248

PAPER Chen P, Wang RR, Ma XJ, Liu Q, Ni JZ

Different Forms of Selenoprotein M Differentially Affect Aβ Aggregation and ROS Generation.

Int J Mol Sci. 2013;14(3):4385-99. PubMed: 23439548

PAPER Bai F, Xu Y, Chen J, Liu Q, Gu J, Wang X, Ma J, Li H, Onuchic JN, Jiang H

Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4273-8. PubMed: 23440190

PAPER Malm T, Magga J, Koistinaho J

Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance.

Curr Transl Geriatr Exp Gerontol Rep. 2012 Mar;1(1):11-20. PubMed: 23440676

PAPER Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E

Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster.

Chembiochem. 2013 Mar 18;14(5):583-92. PubMed: 23440928

PAPER Chen N, Yang M, Guo J, Zhou M, Zhu C, He L

Cerebrolysin for vascular dementia.

Cochrane Database Syst Rev. 2013;1:CD008900. PubMed: 23440834

PAPER Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G, Bolognesi ML, Piomelli D, Reggiani A, Cavalli A

Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease.

PLoS One. 2013;8(2):e56870. PubMed: 23441223

PAPER Zhang B, Tian M, Zheng H, Zhen Y, Yue Y, Li T, Li S, Marcantonio ER, Xie Z

Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and Tau Level.

Anesthesiology. 2013 Feb 22; PubMed: 23438677

PAPER Brinton RD

Neurosteroids as regenerative agents in the brain: therapeutic implications.

Nat Rev Endocrinol. 2013 Feb 26; PubMed: 23438839

PAPER Irwin DJ, Trojanowski JQ, Grossman M

Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease.

Front Aging Neurosci. 2013;5:6. PubMed: 23440936

Robert McArthur on New Frontier: Developing Outcome Measures for Pre-dementia Trials

COMMENT Neuropsychiatric drug discovery and development are undergoing a severe crisis, as many high-profile potential drugs with novel mechanisms of action fail to show clinical efficacy at Phase 3. These failures are prompting large pharmaceutical companies to

PAPER McArthur R

Many are called, yet few are chosen. Are neuropsychiatric clinical trials letting us down?

Drug Discov Today. 2011 Mar;16(5-6):173-5. PubMed: 21163366

Nandini Raghavan

Johnson & Johnson
New York, United States