Can Transferrin Antibodies Safely Open the Blood-Brain Barrier?

RESEARCH NEWS 2013-05-03 Research News For decades scientists have sought a way to sneak large drugs across the blood-brain barrier. These efforts received a boost in 2011, when researchers led by Ryan Watts at Genentech, South San Francisco, California, reported using bispecific

Do Microglia in the Hypothalamus Drive Aging?

RESEARCH NEWS 2013-05-03 Research News Microglia have taken center stage in Alzheimer’s disease (AD) research recently. Not only have genetics studies pinpointed variants in the microglial receptor TREM2 as major risk factors for AD (see ARF related news story), but tuning down m

PAPER van Dijk KD, Bidinosti M, Weiss A, Raijmakers P, Berendse HW, van de Berg WD

Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity.

Eur J Neurol. 2013 Apr 30; PubMed: 23631635

PAPER Freeman D, Cedillos R, Choyke S, Lukic Z, McGuire K, Marvin S, Burrage AM, Sudholt S, Rana A, O'Connor C, Wiethoff CM, Campbell EM

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.

PLoS One. 2013;8(4):e62143. PubMed: 23634225

PAPER Herzog CD, Brown L, Kruegel BR, Wilson A, Tansey MG, Gage FH, Johnson EM, Bartus RT

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120).

Neurobiol Dis. 2013 Apr 28;58C:38-48. PubMed: 23631873

PAPER Jouroukhin Y, Ostritsky R, Assaf Y, Pelled G, Giladi E, Gozes I

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.

Neurobiol Dis. 2013 Aug;56:79-94. PubMed: 23631872

PAPER Zhou C, Zhang C, Zhao R, Chi S, Ge P

Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis.

J Neuroinflammation. 2013;10:52. PubMed: 23631660

PAPER Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD

The emergence of functional microcircuits in visual cortex.

Nature. 2013 Apr 4;496(7443):96-100. PubMed: 23552948

PAPER Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, Dewitt DS, Kayed R

Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.

J Biol Chem. 2013 Jun 7;288(23):17042-50. PubMed: 23632019

PAPER Huang YD, Shuai JW

Induced dipoles incorporated into all-atom Zn protein simulations with multiscale modeling.

J Phys Chem B. 2013 May 23;117(20):6138-48. PubMed: 23631342

PAPER Kalenzaga S, Clarys D

Self-referential processing in Alzheimer's disease: two different ways of processing self-knowledge?

J Clin Exp Neuropsychol. 2013;35(5):455-71. PubMed: 23631426

PAPER Ahmed HH, Salem AM, Sabry GM, Husein AA, Kotob SE

Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats.

J Med Food. 2013 May;16(5):437-46. PubMed: 23631499

PAPER Nishikawa T, Takahashi T, Nakamori M, Yamazaki Y, Kurashige T, Nagano Y, Nishida Y, Izumi Y, Matsumoto M

Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles.

Neuropathol Appl Neurobiol. 2013 Apr 30; PubMed: 23631697

PAPER Chouinard-Watkins R, Rioux-Perreault C, Fortier M, Tremblay-Mercier J, Zhang Y, Lawrence P, Vohl MC, Perron P, Lorrain D, Brenna JT, Cunnane SC, Plourde M

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele.

Br J Nutr. 2013 Apr 30;:1-9. PubMed: 23631810

PAPER Zhang T, Davatzikos C

Optimally-Discriminative Voxel-Based Morphometry significantly increases the ability to detect group differences in schizophrenia, mild cognitive impairment, and Alzheimer's disease.

Neuroimage. 2013 Oct 1;79:94-110. PubMed: 23631985