bhakti patel

cuttack, India

Rui Hua

China

Paris: More Trial News, Mixed at Best

CONFERENCE COVERAGE 2011-08-02 Conference Coverage Updated 03 August 2011. With the buzz surrounding amyloid-targeting therapies, it is easy to lose sight of the fact that other treatments are being tested as well. Presentations at the 11th annual Alzheimer’s Association International

Hedgehog Protocol Turns Supersonic in Faster Route to Motor Neurons

RESEARCH NEWS 2011-08-02 Research News It takes sonic hedgehog, retinoic acid, and more than a month to turn stem cells into a few motor neurons for study or, eventually, transplantation. For researchers keen to understand amyotrophic lateral sclerosis and other motor neuron cond

Sam Gandy on LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

COMMENT This work looks very solid and very interesting. We seem to have moved from the “secretase generation” to the “sortase generation,” what with LRP, vps35, SORL1, and SORCS1 all playing key roles in sorting APP and its C-terminal fragments in and out of Aβ-

G. William Rebeck on LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

COMMENT This work from Dudley Strickland's lab describes a new protein related to the LDL receptor family, termed LRAD3. This protein shares structural similarities to other members of the family, including domains for the internalization and sorting of (as

PAPER Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.

Cell. 1995 Jul 28;82(2):331-40. PubMed: 7543026

Carol Vasquez

Panama

Adeola Moses

Nigeria

Paris: Semagacestat Autopsy and Other News of Trial Tribulations

CONFERENCE COVERAGE 2011-08-01 Conference Coverage Last August, Eli Lilly and Company halted Phase 3 clinical trials of semagacestat, its γ-secretase inhibitor, after its Data Safety Monitoring Board discovered that patients on the medication fared worse on cognitive symptoms than thos

Research Brief: Novel Sorting Protein May Affect Amyloid Production

RESEARCH NEWS 2011-08-01 Research News The family of low-density lipoprotein (LDL) receptors has captured the interest of Alzheimer’s researchers, because several of these transmembrane sorting proteins help cells crank out Aβ. In the July 27 Journal of Neuroscience, researchers

PAPER Lee HJ, Kang SJ, Lee K, Im H

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):526-31. PubMed: 21798244

PAPER Pihlstrøm L, Toft M

Genetic variability in SNCA and Parkinson's disease.

Neurogenetics. 2011 Nov;12(4):283-93. PubMed: 21800132

PAPER Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM

Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons.

J Biol Chem. 2011 Sep 23;286(38):33310-21. PubMed: 21799010

PAPER Fan LW, Tien LT, Lin RC, Simpson KL, Rhodes PG, Cai Z

Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.

Neurobiol Dis. 2011 Dec;44(3):304-16. PubMed: 21798348