ApoE (8J295)

ANTIBODY monoclonal 8J295 manufacturer cat# LS-C69187<br />manufactured by LifeSpan Biosciences Apolipoprotein E <em>not</em> mouse or rat IgG Apolipoproteins Autogen Bioclear Rabbit Human ApoE http://alzforum.org/res/com/ant/default.asp?antibody

Henrik Zetterberg on Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.

COMMENT This is exactly what we saw in humans treated with GSI as reported in our recent Alzheimer's Research & Therapy paper (Portelius et al., 2010). Similar results have also been seen in cell lines (Portelius et al., 2009), mice (Portelius et al., 20

Yanosh Sanotsky

United States

PAPER Guo Z, Shi F, Zhang L, Zhang H, Yang J, Li B, Jia J, Wang X

Critical role of L-type voltage-dependent Ca2+ channels in neural progenitor cell proliferation induced by hypoxia.

Neurosci Lett. 2010 Jul 12;478(3):156-60. PubMed: 20466036

PAPER Guzel A, Karasalihoglu S, Aylanç H, Temizöz O, Hiçdönmez T

Validity of serum tau protein levels in pediatric patients with minor head trauma.

Am J Emerg Med. 2010 May;28(4):399-403. PubMed: 20466216

PAPER Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U

Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-

J Med Chem. 2010 Jun 10;53(11):4379-89. PubMed: 20465311

PAPER Bunch TJ, Weiss JP, Crandall BG, May HT, Bair TL, Osborn JS, Anderson JL, Muhlestein JB, Horne BD, Lappe DL, Day JD

Letter to the editor-response: atrial fibrillation is independently associated with senile, vascular, and alzheimer's dementia.

Heart Rhythm. 2010 May 11; PubMed: 20466072

PAPER Kiris E, Ventimiglia D, Feinstein SC

Quantitative analysis of MAP-mediated regulation of microtubule dynamic instability in vitro focus on Tau.

Methods Cell Biol. 2010;95:481-503. PubMed: 20466149

PAPER Kring SI, Brummett BH, Barefoot J, Garrett ME, Ashley-Koch AE, Boyle SH, Siegler IC, Sørensen TI, Williams RB

Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.

Psychosom Med. 2010 Jun;72(5):427-33. PubMed: 20467002

PAPER Arai H, Okamura N, Furukawa K, Kudo Y

Geriatric medicine, Japanese Alzheimer's disease neuroimaging initiative and biomarker development.

Tohoku J Exp Med. 2010;221(2):87-95. PubMed: 20467230

PAPER Salem MY, El-Kosasy AM, El-Bardicy MG, Abd El-Rahman MK

Spectrophotometric and spectrodensitometric methods for the determination of rivastigmine hydrogen tartrate in presence of its degradation product.

Drug Test Anal. 2010 May;2(5):225-33. PubMed: 20468010

PAPER Steel K

Alzheimer's disease.

N Engl J Med. 2010 May 13;362(19):1844; author reply 1844-5. PubMed: 20468086

Raising Our...Hoops?—No Rebounds With γ-Secretase Inhibitors

RESEARCH NEWS 2010-05-16 Research News Rebounds leave basketball fans on the edge of their seats. They can also leave drug developers with bated breath—rebounds of the Aβ kind, that is. Research shows that withdrawal of γ-secretase inhibitors (GSIs) unleashes a sudden spike in Aβ

PAPER Nainar PG, Green DW, Arden JR

Cognitive decline in older subjects.

Anesthesiology. 2010 May;112(5):1281-2; author reply 1283-5. PubMed: 20418704

PAPER Mackowiak MA

[Vascular dementia].

Presse Med. 2010 Jul-Aug;39(7-8):799-806. PubMed: 20466512