PAPER Kim J, Kim SH, Lee DS, Lee DJ, Chung S, Yang HO
SEARCH RESULTS
330889 RESULTS
PAPER Holtzman JL
Cellular and animal models for high-throughput screening of therapeutic agents for the treatment of the diseases of the elderly in general and Alzheimer's disease in particular(†).
Front Pharmacol. 2013;4:59. PubMed: 23717280PAPER Ariga T, Kubota M, Nakane M, Oguro K, Yu RK, Ando S
Anti-Chol-1 antigen, GQ1bα, antibodies are associated with Alzheimer's disease.
PLoS One. 2013;8(5):e63326. PubMed: 23717411PAPER Jansen D, Zerbi V, Janssen CI, Dederen PJ, Mutsaers MP, Hafkemeijer A, Janssen AL, Nobelen CL, Veltien A, Asten JJ, Heerschap A, Kiliaan AJ
A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and AβPPswe-PS1dE9 mice.
PLoS One. 2013;8(5):e63643. PubMed: 23717459PAPER Rahman A, Languille S, Lamberty Y, Babiloni C, Perret M, Bordet R, Blin OJ, Jacob T, Auffret A, Schenker E, Richardson J, Pifferi F, Aujard F
Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur.
PLoS One. 2013;8(5):e64493. PubMed: 23717620PAPER Henriksen K, Wang Y, Sørensen MG, Barascuk N, Suhy J, Pedersen JT, Duffin KL, Dean RA, Pajak M, Christiansen C, Zheng Q, Karsdal MA
An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function.
PLoS One. 2013;8(5):e64990. PubMed: 23717682PAPER Wang Q, Yu X, Li L, Zheng J
Inhibition of Amyloid-β Aggregation in Alzheimer Disease.
Curr Pharm Des. 2013 May 22; PubMed: 23713775PAPER Shamirian S, Nalbandian A, Khare M, Castellani R, Kim R, Kimonis VE
Early-onset Alzheimers and Cortical Vision Impairment in a Woman With Valosin-containing Protein Disease Associated With 2 APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 Genotype.
Alzheimer Dis Assoc Disord. 2013 May 24; PubMed: 23715207PAPER Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM
Steroids as γ-secretase modulators.
FASEB J. 2013 May 28; PubMed: 23716494PAPER Kříž Z, Klusák J, Krištofíková Z, Koča J
How ionic strength affects the conformational behavior of human and rat beta amyloids--a computational study.
PLoS One. 2013;8(5):e62914. PubMed: 23717395PAPER Schedin-Weiss S, Inoue M, Teranishi Y, Yamamoto NG, Karlström H, Winblad B, Tjernberg LO
Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.
PLoS One. 2013;8(5):e63962. PubMed: 23717518Courtney Sutphen
United States
MAPT I260V
MUTATIONS MAPT 44073986 GRCh37/hg19 rs63751249 A G g.110026A> G g.107200A> G I595V Exon 9 Point, Missense Coding Selective increase in tau aggregation (four-repeat isoforms only); No disruption of exon 10 splicing. Extensive tau pathology, but no neurofibrill
MAPT K257T
MUTATIONS MAPT 44073978 GRCh37/hg19 rs63750129 A C g.110018A> C g.107192A> C Exon 9 Point, Missense Coding Impairs its own lysosomal degradation; reduces ability to promote microtubule assembly. Frontotemporal atrophy, especially in the temporal lobes. Numero
PSEN1 R269H
MUTATIONS PSEN1 73664775 GRCh37/hg19 rs63750900 G A g.49991G> A g.66597G> A Exon 8 Point, Missense Coding Decreased the Aβ (37 + 38 + 40) / (42 + 43) ratio in cells; decreased γ-secretase activity (53% of wildtype). Neuropathology consistent with Alzheimer�
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