PAPER Hartz S, Getsios D, Tao S, Blume S, Maclaine G

Evaluating the cost effectiveness of donepezil in the treatment of Alzheimer's disease in Germany using discrete event simulation.

BMC Neurol. 2012;12:2. PubMed: 22316501

PAPER Menuet C, Borghgraef P, Voituron N, Gestreau C, Gielis L, Devijver H, Dutschmann M, Van Leuven F, Hilaire G

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases.

Neurobiol Dis. 2012 Apr;46(1):234-43. PubMed: 22316605

PAPER

Upcoming meetings related to Alzheimer's disease.

J Biol Chem. 2010 Jul 30;285(31):24108-19. PubMed: 22316637

PAPER Houacine J, Bolmont T, Aeschbach L, Oulad-Abdelghani M, Fraering PC

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides.

Neurobiol Aging. 2012 Feb 6; PubMed: 22317957

PAPER Núñez MT, Urrutia P, Mena N, Aguirre P, Tapia V, Salazar J

Iron toxicity in neurodegeneration.

Biometals. 2012 Feb 9; PubMed: 22318507

PAPER Polidori MC, Stahl W, De Spirt S, Pientka L

[Influence of vascular comorbidities on the antioxidant defense system in Alzheimer's disease].

Dtsch Med Wochenschr. 2012 Feb;137(7):305-8. PubMed: 22318842

PAPER Walker Z, McKeith I, Rodda J, Qassem T, Tatsch K, Booij J, Darcourt J, O'brien J

Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer's disease: a cohort study.

BMJ Open. 2012;2:e000380. PubMed: 22318660

PAPER Regan K, Wang K, Doughty E, Li H, Li J, Lee Y, Kann MG, Lussier YA

Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants.

J Am Med Inform Assoc. 2012 Mar-Apr;19(2):306-16. PubMed: 22319180

PAPER Clos AL, Kayed R, Lasagna-Reeves CA

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis.

Front Neurol. 2012;3:5. PubMed: 22319507

PAPER Imanishi T, Hossain MM, Suzuki T, Xu P, Sato I, Kobayashi H

Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats.

Adv Pharmacol Sci. 2012;2012:708178. PubMed: 22319525

PAPER Lee JY, Cho E, Seo JW, Hwang JJ, Koh JY

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.

J Neuropathol Exp Neurol. 2012 Mar;71(3):211-22. PubMed: 22318122

PAPER Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X

The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.

J Neuropathol Exp Neurol. 2012 Mar;71(3):233-41. PubMed: 22318126

PAPER Miklós I, Zádori Z

Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.

PLoS Comput Biol. 2012 Feb;8(2):e1002356. PubMed: 22319430

Dennis Selkoe on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

COMMENT Since our publication (Bartels et al., 2011), we have conducted extensive experiments using both Clear Native (CN) PAGE and in-vivo crosslinking of endogenous cellular α-synuclein. Regarding the former method, the migration of endogenous human α-synuclein

Leon Tai on Upping Brain ApoE, Drug Treats Alzheimer's Mice

COMMENT The issue of whether to increase or decrease ApoE levels for AD therapy is confounded by the multiple functions of ApoE. In a landmark paper, Landreth and coworkers clearly demonstrate that bexarotene treatment, an RXR agonist, increases endogenous mouse