PAPER Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Williams S

Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?

Int J Alzheimers Dis. 2012;2012:276803. PubMed: 22779025

PAPER Lue LF, Andrade C, Sabbagh M, Walker D

Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer's Disease?

Int J Alzheimers Dis. 2012;2012:918680. PubMed: 22779027

PAPER Liu Y, Koyutürk M, Maxwell S, Zhao Z, Chance MR

Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data.

AMIA Summits Transl Sci Proc. 2012;2012:62-71. PubMed: 22779053

PAPER Bezprozvanny I

Presenilins: a novel link between intracellular calcium signaling and lysosomal function?

J Cell Biol. 2012 Jul 9;198(1):7-10. PubMed: 22778275

PAPER García-Barroso C, Ricobaraza A, Pascual-Lucas M, Unceta N, Rico AJ, Goicolea MA, Sallés J, Lanciego JL, Oyarzabal J, Franco R, Cuadrado-Tejedor M, García-Osta A

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

Neuropharmacology. 2013 Jan;64:114-23. Epub 2012 Jul 7 PubMed: 22776546

PAPER Kingwell K

Alzheimer disease: Amyloid-β immunotherapy CAD106 passes first safety test in patients with Alzheimer disease.

Nat Rev Neurol. 2012 Aug;8(8):414. PubMed: 22777243

PAPER Shively S, Scher AI, Perl DP, Diaz-Arrastia R

Dementia Resulting From Traumatic Brain Injury: What Is the Pathology?

Arch Neurol. 2012 Jul 9;:1-7. PubMed: 22776913

PAPER Weitz TM, Town T

Microglia in Alzheimer's Disease: It's All About Context.

Int J Alzheimers Dis. 2012;2012:314185. PubMed: 22779026

Elizabeth Garlich

United States

Allan Marshall

Manassas, United States

Chris Carter on Paper Alert: Stress Granules Get Tangled Up in Tau

COMMENT Stress granules are commonly induced by viruses, including herpes simplex, and there is a recent review on the process in PLoS Pathogens. chris_car 0 Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic

PAPER Esclatine A, Taddeo B, Roizman B

Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.

J Virol. 2004 Aug;78(16):8582-92. PubMed: 15280467

PAPER Lloyd RE

How do viruses interact with stress-associated RNA granules?

PLoS Pathog. 2012 Jun;8(6):e1002741. PubMed: 22761570

Carlos Vázquez on Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.

COMMENT I enjoyed this article. It is a well-performed study to assess the usefulness of plasma neurosin as a biomarker for AD. 0 carvaper

Nikolaos K. Robakis on Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.

COMMENT This is a very interesting work, showing for the first time that increasing neuronal cAMP prevents caspase activation, tau cleavage, and neuronal cell death. The data in the paper support the suggestion that increasing proteasome activity in a sustainable