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PAPER Beck J, Poulter M, Hensman D, Rohrer JD, Mahoney CJ, Adamson G, Campbell T, Uphill J, Borg A, Fratta P, Orrell RW, Malaspina A, Rowe J, Brown J, Hodges J, Sidle K, Polke JM, Houlden H, Schott JM, Fox NC, Rossor MN, Tabrizi SJ, Isaacs AM, Hardy J, Warren JD, Collinge J, Mead S

Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.

Am J Hum Genet. 2013 Mar 7;92(3):345-53. Epub 2013 Feb 21 PubMed: 23434116

Luc Buee on Exploring Genome Fragmentation in Neurodegeneration

COMMENT We all agree that DNA damage increases with aging. Many proteins described in neurodegenerative disorders may be involved in this process. A key one is once again forgotten: tau. Luc.Buee 0 Nuclear tau, a key player in neuronal DNA protection.

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