PAPER Nilsen J, Morales A, Brinton RD

Medroxyprogesterone acetate exacerbates glutamate excitotoxicity.

Gynecol Endocrinol. 2006 Jul;22(7):355-61. PubMed: 16864144

PAPER Nilsen J, Brinton RD

Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10506-11. PubMed: 12925744

PAPER Gallego MJ, Porayette P, Kaltcheva MM, Meethal SV, Atwood CS

Opioid and progesterone signaling is obligatory for early human embryogenesis.

Stem Cells Dev. 2009 Jun;18(5):737-40. PubMed: 18803462

PAPER Frye CA, Walf AA

Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks.

Neurobiol Learn Mem. 2008 Jul;90(1):171-7. PubMed: 18455450

Kentaro Hayashi

University of Wisconsin-Madison
Madison, United States

A. David Smith on Toronto: 6th Sense—GWAS Picks Up New AD Risk Variant

COMMENT The enzyme MTHFD1L does not directly catalyze the conversion of homocysteine to methionine. Also, there is no current evidence that mutations in the gene for MTHFD1L cause elevated homocysteine levels. The finding that a variant of MTHFD1L is linked to th

PAPER MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ

Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

J Biol Chem. 2009 Jan 16;284(3):1533-9. PubMed: 19033438

sagaram shashidar

Hyderabad, India

Roberta Diaz Brinton on News Flash: NYT Story Traces Estrogen’s Effect on Aging Brain

COMMENT Dear colleagues, I recommend the New York Times article by Cynthia Gorney as an excellent story relevant to woman's health, aging and the challenge of communicating science and its complexity to the public. The blog comments provide a window into the

American Academy of Neurology: 2010 Annual Meeting

CONFERENCE COVERAGE SERIES Toronto: 6th Sense—GWAS Picks Up New AD Risk Variant Toronto: Mucke, Miller Share Prestigious Potamkin Prize Toronto: In Small Trial, IVIg Slows Brain Shrinkage American Academy of Neurology: 2010 Annual Meeting

Franz Hefti

Prevail Therapeutics Inc.
New York, United States

Toronto: In Small Trial, IVIg Slows Brain Shrinkage

CONFERENCE COVERAGE 2010-04-20 Conference Coverage There may be a new reason to support your local phlebotomist—if data from an extension trial of 24 people hold up in Phase 3, that is. A preparation of human blood immunoglobulins slows clinical decline in Alzheimer patients and protec

Walter Bradley DM, FRCP

United States

Theresa Branchek

SubArbore Consulting
Oceanside, United States

PAPER Jak AJ, Bondi MW, Delano-Wood L, Wierenga C, Corey-Bloom J, Salmon DP, Delis DC

Quantification of five neuropsychological approaches to defining mild cognitive impairment.

Am J Geriatr Psychiatry. 2009 May;17(5):368-75. PubMed: 19390294