PAPER Su K, Bourdette D, Forte M
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PAPER Nicolazzo JA, Banks WA
Decreased blood-brain barrier expression of P-glycoprotein in Alzheimer's disease: impact on pathogenesis and brain access of therapeutic agents.
Ther Deliv. 2011 Jul;2(7):841-4. PubMed: 22833898PAPER Sanz JM, Chiozzi P, Colaianna M, Zotti M, Ferrari D, Trabace L, Zuliani G, Di Virgilio F
Nimodipine inhibits amyloid β-stimulated IL-1β release from microglia.
Br J Pharmacol. 2012 Jul 25; PubMed: 22831460PAPER Valenzuela M, Esler M, Ritchie K, Brodaty H
Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention.
Transl Psychiatry. 2012;2:e107. PubMed: 22832907Jürgen Götz on Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
COMMENT Of all Src kinases, Fyn is assuming a critical role in mediating Aβ toxicity. In this Nature Neuroscience paper, Stephen Strittmatter and colleagues show that oligomeric forms of Aβ bind to PrPC, a protein on the extracellular side of the membrane, and th
Baindu Bayon
United States
Wave of New BACE Inhibitors Heading to Phase 2
CONFERENCE COVERAGE 2012-07-27 Conference Coverage Many had trouble reaching the brain. Or they got in but couldn’t stay, ousted in short order by P-glycoprotein. At long last, drug developers have overcome these and other hurdles, and well over a decade of effort developing β-secretas
Makoto Ishii
Weill Medical College of Cornell UniversityNew York, United States
PAPER Moher D, Schulz KF, Altman DG
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials.
Lancet. 2001 Apr 14;357(9263):1191-4. PubMed: 11323066PAPER Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC,
Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic Accuracy.
Clin Chem. 2003 Jan;49(1):1-6. PubMed: 12507953Tracing Aβ’s Toxicity Through Prion Protein, Fyn Kinase
RESEARCH NEWS 2012-07-27 Research News Oligomers are widely believed to be the most neurotoxic Aβ species, but how they exert their harmful effects remains mysterious. Previously, researchers led by Stephen Strittmatter at Yale University, New Haven, Connecticut, reported that at
PAPER O'Callaghan C, Hodges JR, Hornberger M
Inhibitory Dysfunction in Frontotemporal Dementia: A Review.
Alzheimer Dis Assoc Disord. 2012 Jul 20; PubMed: 22828322PAPER Dara C, Kirsch-Darrow L, Ochfeld E, Slenz J, Agranovich A, Vasconcellos-Faria A, Ross E, Hillis AE, Kortte KB
Impaired emotion processing from vocal and facial cues in frontotemporal dementia compared to right hemisphere stroke.
Neurocase. 2012 Jul 25; PubMed: 22827701PAPER Furukawa Y
Pathological roles of wild-type cu, zn-superoxide dismutase in amyotrophic lateral sclerosis.
Neurol Res Int. 2012;2012:323261. PubMed: 22830015PAPER Zhao Y, Luo P, Guo Q, Li S, Zhang L, Zhao M, Xu H, Yang Y, Poon W, Fei Z
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo.
Exp Neurol. 2012 Oct;237(2):489-98. PubMed: 22828134Current Filters
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