PAPER Kuba H, Oichi Y, Ohmori H
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PAPER Grubb MS, Burrone J
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
Nature. 2010 Jun 24;465(7301):1070-4. PubMed: 20543823Kostas Vekrellis on Excess α-Synuclein Sends Synapses Sputtering
COMMENT α-synuclein and Synaptic Failure in PD α-synuclein has been biochemically and genetically linked to sporadic and familial PD. Mutations or multiplications of the α-synuclein gene cause familial forms of PD (Polymeropoulos et al., 1997; Krüger et al., 1998
Walter J. Schulz-Schaeffer on Excess α-Synuclein Sends Synapses Sputtering
COMMENT Both papers present evidence that the pathophysiological mechanism in synucleinopathies is not neuronal cell death but a synaptic dysfunction; that is very interesting. With regard to the clinical symptoms in PD, (also PDD and DLB), the synaptic pathology
Martin Ingelsson on Excess α-Synuclein Sends Synapses Sputtering
COMMENT The work by Scott and colleagues is of great interest as it is trying to pinpoint the molecular details in the synaptic pathology caused by a modest transgenic overexpression of α-synuclein. The authors found that PK-resistant and abnormally phosphorylate
Robert Edwards on Excess α-Synuclein Sends Synapses Sputtering
COMMENT The background for our work is that α-synuclein normally localizes to the axon terminal of essentially all neurons, but its role, if any, in neurotransmitter release has remained very unclear. In general, knockout mice have shown either no effect or confl
Subhojit Roy on Excess α-Synuclein Sends Synapses Sputtering
COMMENT Our goal in this study was to try connecting the dots between two key pathologic events: modestly elevated α-synuclein levels within the neuron and the ultimate synaptic dysfunction. We used a cell-biological approach that allowed us to analyze and quanti
Mathew Blurton-Jones on A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.
COMMENT This elegant study by Scott et al. takes advantage of primary neuron cultures from α-synuclein-GFP-transgenic mice to examine the effects of modest α-synuclein overexpression on presynaptic proteins. They find convincing evidence that α-synuclein can dimi
Amyloid Beta 42, high-sensitive
ANTIBODY kit manufacturer cat# 290-64501<br />Wako <a href="http://www.wako-chem.co.jp/english/labchem/pdf/bAmyloidKits.pdf" target="_new">Kit Page</a><br />(see also<br />Cat# <a href="/antibodies/amyloid-
PAPER Deitcher DL, Ueda A, Stewart BA, Burgess RW, Kidokoro Y, Schwarz TL
Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.
J Neurosci. 1998 Mar 15;18(6):2028-39. PubMed: 9482790PAPER Nonet ML, Saifee O, Zhao H, Rand JB, Wei L
Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.
J Neurosci. 1998 Jan 1;18(1):70-80. PubMed: 9412487PAPER Schoch S, Deák F, Königstorfer A, Mozhayeva M, Sara Y, Südhof TC, Kavalali ET
SNARE function analyzed in synaptobrevin/VAMP knockout mice.
Science. 2001 Nov 2;294(5544):1117-22. PubMed: 11691998PAPER Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, Stefanis L, Sulzer D
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.
J Neurosci. 2006 Nov 15;26(46):11915-22. PubMed: 17108165PAPER Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Nat Genet. 1998 Feb;18(2):106-8. PubMed: 9462735PAPER Senior SL, Ninkina N, Deacon R, Bannerman D, Buchman VL, Cragg SJ, Wade-Martins R
Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein.
Eur J Neurosci. 2008 Feb;27(4):947-57. PubMed: 18333965Current Filters
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