PAPER Huber K, Superti-Furga G

After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.

Bioorg Med Chem. 2011 Jun 15;19(12):3616-24. PubMed: 21306906

PAPER Narver HL, Kong L, Burnett BG, Choe DW, Bosch-Marcé M, Taye AA, Eckhaus MA, Sumner CJ

Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition.

Ann Neurol. 2008 Oct;64(4):465-70. PubMed: 18661558

PAPER Swoboda KJ, Prior TW, Scott CB, McNaught TP, Wride MC, Reyna SP, Bromberg MB

Natural history of denervation in SMA: relation to age, SMN2 copy number, and function.

Ann Neurol. 2005 May;57(5):704-12. PubMed: 15852397

PAPER Kariya S, Park GH, Maeno-Hikichi Y, Leykekhman O, Lutz C, Arkovitz MS, Landmesser LT, Monani UR

Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy.

Hum Mol Genet. 2008 Aug 15;17(16):2552-69. PubMed: 18492800

PAPER Passini MA, Bu J, Roskelley EM, Richards AM, Sardi SP, O'Riordan CR, Klinger KW, Shihabuddin LS, Cheng SH

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

J Clin Invest. 2010 Apr 1;120(4):1253-64. PubMed: 20234094

PAPER Kales HC, Zivin K, Kim HM, Valenstein M, Chiang C, Ignacio RV, Ignacio R, Ganoczy D, Cunningham F, Schneider LS, Blow FC

Trends in antipsychotic use in dementia 1999-2007.

Arch Gen Psychiatry. 2011 Feb;68(2):190-7. PubMed: 21300946

PAPER Ayalon L, Gum AM, Feliciano L, Areán PA

Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review.

Arch Intern Med. 2006 Nov 13;166(20):2182-8. PubMed: 17101935

PAPER Saad M, Cassagnol M, Ahmed E

The impact of FDA's warning on the use of antipsychotics in clinical practice: a survey.

Consult Pharm. 2010 Nov;25(11):739-44. PubMed: 21138822

PAPER , Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

Lancet. 2011 Feb 19;377(9766):641-9. PubMed: 21292315

PAPER Conway CD, Howe KM, Nettleton NK, Price DJ, Mason JO, Pratt T

Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.

J Neurosci. 2011 Feb 9;31(6):1955-70. PubMed: 21307234

M. Flint Beal on Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

COMMENT This is an impressive amount of work done by Dr. Yan and colleagues. The results strongly implicate a critical role for Aβ in mitochondria for AD pathogenesis. The finding that blocking the interaction of Aβ with Aβ peptide-binding alcohol dehydrogenase a

Hsc70 /Hsp73 (1B5)

ANTIBODY monoclonal 1B5 manufacturer SPA-815<br />Reference: <br /><a href="/papers/alpha-synuclein-promotes-snare-complex-assembly-vivo-and-vitro" target="_new">Burré J, 2010</a> immunogen = native hamster Hsc70 (Hsp73)

Russell Swerdlow on Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

COMMENT In this paper, the Yan lab does a remarkable job following up on its seminal 2004 work that showed Aβ and an alcohol dehydrogenase associate within the mitochondria of mutant APP transgenic mice. The findings in this current paper reinforce the view that

PAPER Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

J Neurosci. 2011 Feb 9;31(6):2313-20. PubMed: 21307267

Barry Boland on Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

COMMENT This paper by Tamboli et al. is an interesting study that highlights the increasing number of lysosomal storage diseases (LSDs) that have elevated amounts of APP-CTFs and Aβ, and indicates the importance of maintaining efficient lysosomal flux as an anti-