CONFERENCE COVERAGE 2016-10-27 Conference Coverage The 2nd Kloster Seeon Meeting on BACE Proteases in Health and Disease, held September 25-27 in Seeon near Munich, was propelled on an updraft of optimism that BACE inhibitors may work out to treat or prevent Alzheimer’s disease (see ...
COMMENT No adverse side effect of β-secretase inhibitors is indeed good news, but something has been bugging me since I read the news. We can attribute the absence of β-secretase inhibitors’ side effect to an alternative cleavage by α-secretase. The α-secretase ...
PAPER Iwatsubo T, Saido TC, Mann DM, Lee VM, Trojanowski JQ
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.Am J Pathol. 1996 Dec;149(6):1823-30. PubMed: 8952519
PAPER Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S8899741
COMMENT The paper is interesting and agrees with our previous studies where we reported multimerization of α-helical α-synuclein in the presence of liposomes and brain membranes that mediate SNARE-complex formation, and the protection of membrane-bound α ...
DayStar Open MRI LLCMcAllen, United States
CONFERENCE COVERAGE SERIES At 2nd Kloster Seeon Meeting, Renewed Optimism for Targeting BACE1 At the second Kloster Seeon meeting, researchers seemed more enthusiastic than ever about the prospect of treating Alzheimer’s with β-secretase inhibitors despite concerns over potential ...
Weill Cornell MedicineNew York, United States
Los Angeles, United States
Sanofi R&DChilly Mazarin Cedex, France
The University of MelbourneMelbourne, Australia
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