Tim Hodges
Landmark Ministries of ArkansasVan Buren, United States
331256 RESULTS
Landmark Ministries of ArkansasVan Buren, United States
COMMENT People with AD are very affected by their surroundings. They get agitated when they need to be hospitalized, or when going to crowded and unfamiliar places. The new data in this paper provide insight into the biological substrate for these symptoms. The a
COMMENT In our comments to Alzforum on 17 February 2012, we reported our failure to confirm the data of Cramer et al. in the APPSwFILon, PSEN1*M146L*L286V (5XFAD) mouse model of Alzheimer's disease. Mice were fed bexarotene 100 mg/kg/day for up to 50 days. W
COMMENT We are very pleased to notice that another group has reproduced our results regarding the transcriptional regulation of BACE1 by PPAR-γ and PGC1-α (Sastre et al., 2006; Katsouri et al., 2011). However, it would have been better if our finding that PGC1-α
PAPER Katsouri L, Parr C, Bogdanovic N, Willem M, Sastre M
University of Campinas-UNICAMPCampinas, Brazil
MUTATIONS PSEN1 73664802 GRCh37/hg19 rs63749891 G C g.50018G> C g.66624G> C Exon 8 Point, Missense Coding Increased Aβ42/Aβ40 ratio and decreased Aβ (37 + 38 + 40) / (42 + 43) and Aβ37/Aβ42 ratios in cells. Also, increased Aβ43 levels 10-fold. Neuropathology
MUTATIONS PSEN1 73664802 GRCh37/hg19 rs63749891 G A g.50018G> A g.66624G> A Exon 8 Point, Missense Coding Increased Aβ42 production in patient fibroblasts; but reduced Aβ42 and Aβ40 production in assay with purified proteins. In both cases, increased Aβ42/Aβ4
MUTATIONS PSEN1 73664790 GRCh37/hg19 rs63750284 C G g.50006C> G g.66612C> G Exon 8 Point, Missense Coding In vitro, Aβ40 and Aβ42 production was undetectable. Unknown T274R Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This mutation was fou
MUTATIONS PSEN1 73664787 GRCh37/hg19 rs63750772 A C g.50003A> C g.66609A> C Exon 8 Point, Missense Coding Increased Aβ43 and decreased Aβ38 in cells; increased Aβ42 and Aβ42/Aβ40 ratio in vitro; disrupted calcium flow in ER. Unknown E273A Alzheimer's Dis
MUTATIONS PSEN1 73664784 GRCh37/hg19 rs63750680 T C g.50000T> C g.66606T> C Exon 8 Point, Missense Coding Increased plasma Aβ42. In vitro, increased Aβ42 production and Aβ42/Aβ40. Neuropathology consistent with AD, but also Lewy bodies in cortex and substanti
MUTATIONS PSEN1 73664780 GRCh37/hg19 rs63750886 C G g.49996C> G g.66602C> G Exon 8 Point, Missense Coding Affects splicing of exon 8 such that more transcripts are produced which lack exon 8. Causes amino acid replacement (D257A) at the splice junction of e
RESEARCH NEWS 2013-05-31 Research News This June, leaders from the globe’s eight richest countries, the G8, will assemble in Northern Ireland to discuss major issues related to the world’s economy—among them, the rising threat of dementia in aging populations. U.K. Prime Minister
RESEARCH NEWS 2013-05-31 Research News Though typically seen as a cognitive disorder, Alzheimer’s disease can throw emotions off kilter, making people unusually sensitive to others’ feelings and moods. New research suggests biological underpinnings for such changes. A report in t
PAPER Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y
No filters selected