COMMENT This study by Brier et al. represents a thoughtful advance in our understanding of the relations between early stage Alzheimer’s disease pathology, measured using PET and CSF measures for amyloid as well as tau, and both clinical and cognitive measures. ...
COMMENT The ability to study the interplay between Aβ and tau in vivo across the aging-to-AD spectrum is incredibly exciting and in my opinion highly likely to yield new insights into disease mechanisms. This study adds to a growing literature on this topic (e.g. ...
PAPER Sengupta U, Nilson AN, Kayed R27211547
COMMENT In this paper, Brier and colleagues investigated the topography of in vivo tau and Aβ deposition in a multimodal setting. This new study offers interesting and innovative approaches to investigate the regional pattern of the pathological markers of ...
RESEARCH NEWS 2016-05-24 Research News Brain metabolism wanes as Alzheimer’s disease worsens, but results from a small trial hint that a diabetes drug may halt the slow-down. Researchers led by Jørgen Rungby at Aarhus University in Denmark reported that AD patients treated with ...
PAPER Gejl M, Lerche S, Egefjord L, Brock B, Møller N, Vang K, Rodell AB, Bibby BM, Holst JJ, Rungby J, Gjedde A
Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain.Front Neuroenergetics. 2013;5:2. Epub 2013 Mar 27 PubMed: 23543638
PAPER Gejl M, Gjedde A, Egefjord L, Møller A, Hansen SB, Vang K, Rodell A, Brændgaard H, Gottrup H, Schacht A, Møller N, Brock B, Rungby J
Massachusetts General Hospital/Harvard Medical SchoolBoston, United States
University College LodonLondon, United Kingdom
PAPER Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET27209644
PAPER Herth MM, Petersen IN, Hansen HD, Hansen M, Ettrup A, Jensen AA, Lehel S, Dyssegaard A, Gillings N, Knudsen GM, Kristensen JL27209485
PAPER Yang L, Jin X, Yan J, Jin Y, Yu W, Wu H, Xu S
Prevalence of dementia, cognitive status and associated risk factors among elderly of Zhejiang province, China in 2014.Age Ageing. 2016 May 21; PubMed: 27209328
PAPER Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, Bai X, Zhang Z, Huo W, Zhao X, Shang S, Wang Q, Zhang C, Ji J
Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia.Protein Cell. 2016 May 21; PubMed: 27209302
PAPER Xue B, Zhao Y, Su J, Miao Q, Miao P, Chen N, Wang Z, Zhang Y, Ma S
In Vitro Intestinal Absorption and Metabolism of Magnoflorine and its Potential Interaction in Coptidis Rhizoma Decoction in Rat.Eur J Drug Metab Pharmacokinet. 2016 May 21; PubMed: 27209587
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