PAPER Moro E, Lozano AM, Pollak P, Agid Y, Rehncrona S, Volkmann J, Kulisevsky J, Obeso JA, Albanese A, Hariz MI, Quinn NP, Speelman JD, Benabid AL, Fraix V, Mendes A, Welter ML, Houeto JL, Cornu P, Dormont D, Tornqvist AL, Ekberg R, Schnitzler A, Timmermann L, Wojtecki L, Gironell A, Rodriguez-Oroz MC, Guridi J, Bentivoglio AR, Contarino MF, Romito L, Scerrati M, Janssens M, Lang AE

Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease.

Mov Disord. 2010 Apr 15;25(5):578-86. PubMed: 20213817

PAPER Fasano A, Romito LM, Daniele A, Piano C, Zinno M, Bentivoglio AR, Albanese A

Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants.

Brain. 2010 Sep;133(9):2664-76. PubMed: 20802207

PAPER Schüpbach WM, Maltête D, Houeto JL, du Montcel ST, Mallet L, Welter ML, Gargiulo M, Béhar C, Bonnet AM, Czernecki V, Pidoux B, Navarro S, Dormont D, Cornu P, Agid Y

Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.

Neurology. 2007 Jan 23;68(4):267-71. PubMed: 17151341

Bo Qin

University of North Carolina at Chapel Hill School of Public Health
Chapel Hill, United States

PAPER Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Science. 2013 Mar 15;339(6125):1335-8. Epub 2013 Feb 7 PubMed: 23393093

PAPER Srivastava RA, Srivastava N, Averna M, Lin RC, Korach KS, Lubahn DB, Schonfeld G

Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway.

J Biol Chem. 1997 Dec 26;272(52):33360-6. PubMed: 9407129

PAPER Wong CM, Yung LM, Leung FP, Tsang SY, Au CL, Chen ZY, Yao X, Cheng CH, Lau CW, Gollasch M, Huang Y

Raloxifene protects endothelial cell function against oxidative stress.

Br J Pharmacol. 2008 Oct;155(3):326-34. PubMed: 18574454

PAPER Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.

Blood. 2009 Sep 10;114(11):2236-43. PubMed: 19561322

PAPER Misiti S, Nanni S, Fontemaggi G, Cong YS, Wen J, Hirte HW, Piaggio G, Sacchi A, Pontecorvi A, Bacchetti S, Farsetti A

Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells.

Mol Cell Biol. 2000 Jun;20(11):3764-71. PubMed: 10805720

PAPER Lee DC, Im JA, Kim JH, Lee HR, Shim JY

Effect of long-term hormone therapy on telomere length in postmenopausal women.

Yonsei Med J. 2005 Aug 31;46(4):471-9. PubMed: 16127770

PAPER Lin J, Kroenke CH, Epel E, Kenna HA, Wolkowitz OM, Blackburn E, Rasgon NL

Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.

Brain Res. 2011 Mar 16;1379:224-31. PubMed: 20965155

PAPER Henderson IC, Berry DA, Demetri GD, Cirrincione CT, Goldstein LJ, Martino S, Ingle JN, Cooper MR, Hayes DF, Tkaczuk KH, Fleming G, Holland JF, Duggan DB, Carpenter JT, Frei E, Schilsky RL, Wood WC, Muss HB, Norton L

Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.

J Clin Oncol. 2003 Mar 15;21(6):976-83. PubMed: 12637460

Elias Akoury

Germany

Second Study Sees Intron in FTLD Gene Translated

RESEARCH NEWS 2013-02-15 Research News Just days after the first report of a highly eccentric translation mechanism in the major genetic forms of ALS and FTLD comes a second paper showing the same phenomenon. In the February 12 Neuron, researchers led by Leonard Petrucelli at the

Does Estrogen Put the Brakes on Aging in ApoE4-Positive Cells?

RESEARCH NEWS 2013-02-15 Research News White blood cells age quickly in post-menopausal women who carry the ApoE4 gene, but estrogen slows that decline, scientists report February 13 in PLoS ONE. Natalie Rasgon at Stanford University School of Medicine, California, and colleagues