Jitin Bali on Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.
COMMENT Poly (I:C) Effects on Alzheimer’s Disease—BACE1 and Hence Aβ Dependent? Causes for sporadic Alzheimer’s disease (AD) are often attributed to amyloid-independent pathways, whereas early onset AD clearly follows the mechanism outlined in the amyloid cascade