PAPER Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave KA

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.

Nature. 2012 May 24;485(7399):517-21. PubMed: 22622581

Shoji Tsuji

University of Tokyo, Graduate School of Medicine
Tokyo, United States

PAPER Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

N Engl J Med. 2012 Aug 30;367(9):795-804. PubMed: 22784036

PAPER Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA

Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.

Science. 1998 Jun 5;280(5369):1610-3. PubMed: 9616125

Eric M. Reiman on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT This elegant and important study finds an association between a rare APP variant and a lower risk of AD, and it provides strong evidence to suggest that the protective effects of this variant may be attributable to reductions in BACE1-mediated APP cleavag

PAPER Corrado L, Battistini S, Penco S, Bergamaschi L, Testa L, Ricci C, Giannini F, Greco G, Patrosso MC, Pileggi S, Causarano R, Mazzini L, Momigliano-Richiardi P, D'Alfonso S

Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population.

J Neurol Sci. 2007 Jul 15;258(1-2):123-7. PubMed: 17462671

Protective APP Mutation Found—Supports Amyloid Hypothesis

RESEARCH NEWS 2012-07-13 Research News Does β amyloid accumulation drive Alzheimer’s disease? In favor of this idea, numerous known mutations in amyloid precursor protein step up Aβ production and lead to early onset AD. Critics of the theory contend, however, that familial AD ma

Paper Alert: DIAN Biomarker Data Show Changes Decades Before AD

RESEARCH NEWS 2012-07-13 Research News Biomarker data from the Dominantly Inherited Alzheimer Network (DIAN) paint a sobering picture, showing that a cascade of pathophysiological changes begins decades before a person is likely to develop familial Alzheimer’s disease. Alzforum h

Oligodendrocytes More Than Myelinators, Potential Players in ALS

RESEARCH NEWS 2012-07-13 Research News Nursemaid oligodendrocytes care for neuronal axons not only by wrapping them in insulating myelin, but also by feeding them lactate, according to two papers in Nature. This is a fairly newfound function for these cells long considered to be

PAPER Qureshi IA, Mehler MF

Epigenetic mechanisms governing the process of neurodegeneration.

Mol Aspects Med. 2012 Jul 7; PubMed: 22782013

PAPER Verhoest PR, Fonseca KR, Hou X, Proulx-Lafrance C, Corman M, Helal CJ, Claffey MM, Tuttle JB, Coffman KJ, Liu S, Nelson F, Kleiman RJ, Menniti FS, Schmidt CJ, Vanase-Frawley M, Liras S

Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disor

J Med Chem. 2012 Jul 25; PubMed: 22780914

PAPER Yang Z, Fan Y, Deng Z, Wu B, Zheng Q

Amyloid precursor protein as a potential marker of malignancy and prognosis in papillary thyroid carcinoma.

Oncol Lett. 2012 Jun;3(6):1227-1230. PubMed: 22783423

PAPER Stroylova YY, Chobert JM, Muronetz VI, Jakubowski H, Haertlé T

N-homocysteinylation of ovine prion protein induces amyloid-like transformation.

Arch Biochem Biophys. 2012 Oct 1;526(1):29-37. PubMed: 22782079

PAPER Qin Z, Luo J, Vandevrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

J Med Chem. 2012 Aug 9;55(15):6784-801. PubMed: 22779770

PAPER Heo JH, Lee ST, Chu K, Oh MJ, Park HJ, Shim JY, Kim M

Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease.

Nutr Neurosci. 2012 Jul 9; PubMed: 22780999