RESEARCH MODELS Modification Details Inactivation of the endogenous mouse APOE by homologous recombination and insertion of a neomycin cassette. Other Phenotypes ApoE is undetectable in the plasma of these homozygous APOE knock-out mice. They are viable and appear health
RESEARCH MODELS Summary Targeted gene replacement was used to replace the endogenous murine APOE gene with the human APOE2 allele. In humans, the APOE2 allele is associated with decreased risk of Alzheimer's disease and an increased risk for type III hyperlipoprotei
RESEARCH MODELS Summary Gene targeting was used to replace the endogenouse murine APOE gene with the human APOE3 allele. On a standard diet, homozygous mice have normal cholesterol and triglyceride levels, but are more susceptible than wild-type animals to diet-induced a
RESEARCH MODELS Summary Gene targeting was used to replace the endogenous murine APOE gene with the human APOE4 allele. The mice are at increased risk of atherosclerosis compared with wild-type animals or mice expressing human APOE3. On a standard chow diet the mice have