PAPER Youdim MB

Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.

Exp Neurobiol. 2013 Mar;22(1):1-10. PubMed: 23585716

PAPER Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL

AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease.

Exp Neurobiol. 2013 Mar;22(1):31-7. PubMed: 23585720

PAPER Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.

PLoS Biol. 2013;11(4):e1001532. PubMed: 23585733

PAPER Marshall GA, Amariglio RE, Sperling RA, Rentz DM

Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease?

Neurodegener Dis Manag. 2012 Oct 1;2(5):483-491. PubMed: 23585777

Miguel Rodríguez-Manotas on Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.

COMMENT This paper opens a new way to fight AD. It breaks the paradigm in the sense that upregulating, but not inhibiting, presenilin leads to decreased Aβ42 levels. 0 mmanotas

Andrew Sutton on Quick-and-Early IVIG Therapy: Hints of Promise?

COMMENT This result makes me wonder if there is overlap between IVIG and colostrum, because the latter contains many antibodies, and in the case of Colostrinin®, also proline-rich peptides (PRP). Researchers at the University of Texas Medical Branch at Galveston

S. Choon Tay on In Pursuit of Toxic Tau

COMMENT Most protein aggregation follows sigmoid kinetics. Likewise, tau initially aggregates slowly, but ultimately will accelerate exponentially irrespective of whether there is the presence of β amyloid. tayschoon 0

Irene Knuesel on Like Star Born of Supernova, Plaque Born of Exploded Neuron?

COMMENT We see strikingly similar immunoreactive signals in brain sections from 15-month-old immune-challenged transgenic mice (3xTgAD and ArcAβ lines) and in postmortem AD samples using anti-APP (22C11) and anti-Aβ1-40/42 antibodies, which label dystrophic neuri

PAPER Mazzini A, Incerti M, Favilla R

Interaction of DAPI with pepsin as a function of pH and ionic strength.

Biophys Chem. 1997 Sep 1;67(1-3):65-74. PubMed: 9397519

Sanjay Pimplikar on Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

COMMENT Together with their previous study (1), this paper from the Steinman group leaves little doubt that Aβ peptides (both 40 and 42) exert beneficial effects in the EAE mouse model of MS; they do so by reducing neuroinflammation and attenuating paralysis. The

Nancy Morrison

United States

PAPER Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation.

Neuron. 2013 Apr 10;78(1):94-108. PubMed: 23583109

PAPER Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y, Song J, Song YM, Pao HA, Kim RH, Lu C, Lee SD, Song IS, Shin G, Al-Hasani R, Kim S, Tan MP, Huang Y, Omenetto FG, Rogers JA, Bruchas MR

Injectable, cellular-scale optoelectronics with applications for wireless optogenetics.

Science. 2013 Apr 12;340(6129):211-6. PubMed: 23580530

Pritam Das on Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

COMMENT This fascinating paper by Kurnellas et al. follows up on their previous work showing immunomodulatory properties of amyloid peptides (Aβ40 and 42) and αB-crystallin in ameliorating experimental autoimmune encephalomyelitis (EAE), a model of multiple scler

Guardian Amyloid? Aβ Hexamers Help Multiple Sclerosis Mouse Model

RESEARCH NEWS 2013-04-16 Research News Could amyloid-beta fibrils—which form the hallmark plaques of Alzheimer’s disease (AD)—actually protect the brain? That intriguing possibility caught scientists’ attention last year when Lawrence Steinman’s group at Stanford University in Pa