PAPER Marchant N, Reed B, Sanossian N, Madison C, Dhada R, Kriger S, DeCarli C, Weiner M, Chui H, Jagust W
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PAPER Lehmann M, Ghosh P, Madison C, Corbetta C, Long A, Miller B, Jagust W, Rabinovici G
Diverging PIB and FDG Covariance Patterns Across Clinical Variants of AD.
Human Amyloid Imaging Abstract. 2012 Jan 1;PAPER Cintron A, Rosen R, Ciliax B, Walker L, LeVine III H
PIB Binding in APP-Transgenic Mice Exogenously Seeded with AD-brain Extract.
Human Amyloid Imaging Abstract. 2012 Jan 1;PAPER Amariglio R, Wadsworth L, Lorius N, Becker A, Johnson K, Sperling R, Rentz D
Subjective Cognitive Complaint Is Associated with Increased Amyloid Burden in Cognitively Normal Individuals.
Human Amyloid Imaging Abstract. 2012 Jan 1;Beth Snitz
University of PittsburghPittsburgh, United States
Gary Landreth on ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
COMMENT Reply to comment by Jian-Ping Guo, P.L. McGeer, and Claudia Schwab We communicated the results of our study in advance of publication with these authors. It is important that oral administration of bexarotene employ the micronized form of the drug (Targre
James R. Connor on Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
COMMENT This paper by Lei et al. provides two important novel observations. Firstly, as a parkinsonian model, the tau knockout mice are exciting because they do not show symptoms of disease until 12 months of age; thus, similar to Parkinson’s patients, there is a
Wiep Scheper on Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.
COMMENT In this paper, Hu and colleagues explore the role of the unfolded protein response (UPR) in neurodegeneration of retinal ganglion cells in the context of traumatic optic nerve injury and glaucoma. The data presented may indicate that selective activation
News Focus: 2012 Human Amyloid Imaging Conference
CONFERENCE COVERAGE 2012-02-24 Conference Coverage When 225 researchers from around the world convened in Miami to exchange the latest on β amyloid positron emission tomography (PET) on 12-13 January 2012, there was a palpable sense of urgency. At the 6th Annual Human Amyloid Imaging (
Peptide Sparks Synaptic Plasticity, Improves Memory in Rodents
RESEARCH NEWS 2012-02-24 Research News A small peptide called FGL boosts learning and memory when administered to rodents, and is poised to begin clinical trials in Alzheimer’s disease patients this year. Intriguingly, FGL sharpens memory in wild-type rats as well as in several d
Polyglutamine Protein Promotes Natural Cell Death in Worms
RESEARCH NEWS 2012-02-24 Research News How do glutamine-rich proteins cause neurodegenerative disease? A common theory holds that the excess glutamines make proteins glom together into toxic aggregates that trigger cellular dysfunction and death. But could polyQ proteins activate
PAPER Mioshi E, McKinnon C, Savage S, O'Connor CM, Hodges JR
Improving Burden and Coping Skills in Frontotemporal Dementia Caregivers: A Pilot Study.
Alzheimer Dis Assoc Disord. 2012 Feb 17; PubMed: 22354158PAPER Shimshek DR, Schweizer T, Schmid P, van der Putten PH
Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1.
Sci Rep. 2012;2:262. PubMed: 22355774PAPER Stefanis L
α-Synuclein in Parkinson's Disease.
Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399. PubMed: 22355802PAPER Rose F, Hodak M, Bernholc J
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
Sci Rep. 2011;1:11. PubMed: 22355530Current Filters
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