PAPER Nho K, Shen L, Kim S, Risacher SL, West JD, Foroud T, Jack CR, Weiner MW, Saykin AJ
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PAPER Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J
Correction: genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
PLoS One. 2011;6(2) PubMed: 21347273PAPER Kennedy MA, Kabbani N, Lambert JP, Swayne LA, Ahmed F, Figeys D, Bennett SA, Bryan J, Baetz K
Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.
PLoS Genet. 2011;7(2):e1001299. PubMed: 21347278PAPER To AW, Ribe EM, Chuang TT, Schroeder JE, Lovestone S
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
PLoS One. 2011;6(2):e16991. PubMed: 21347323PAPER Valero J, España J, Parra-Damas A, Martín E, Rodríguez-Álvarez J, Saura CA
Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw,Ind) transgenic mice.
PLoS One. 2011;6(2):e16832. PubMed: 21347380PAPER Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, , Goate AM
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
PLoS One. 2011;6(2):e15918. PubMed: 21347408PAPER Paparcone R, Cranford SW, Buehler MJ
Self-folding and aggregation of amyloid nanofibrils.
Nanoscale. 2011 Apr;3(4):1748-55. PubMed: 21347488PAPER Malek-Ahmadi M, Raj A, Small BJ
Semantic clustering as a neuropsychological predictor for amnestic-MCI.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2011 May;18(3):280-92. PubMed: 21347885PAPER Szigeti K, Doody RS
Should EOAD patients be included in clinical trials?
Alzheimers Res Ther. 2011;3(1):4. PubMed: 21345175PAPER Ceyhan E, Beg MF, Ceritoglu C, Wang L, Morris JC, Csernansky JG, Miller MI, Ratnanather JT
Quantization and analysis of hippocampal morphometric changes due to dementia of Alzheimer type using metric distances based on large deformation diffeomorphic metric mapping.
Comput Med Imaging Graph. 2011 Jun;35(4):275-93. PubMed: 21345652PAPER Mustafiz T, Portelius E, Gustavsson MK, Hölttä M, Zetterberg H, Blennow K, Nordberg A, Lithner CU
Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice.
Neurodegener Dis. 2011;8(5):352-63. PubMed: 21346320PAPER Pao WC, Dickson DW, Crook JE, Finch NA, Rademakers R, Graff-Radford NR
Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically.
Alzheimer Dis Assoc Disord. 2011 Oct;25(4):364-8. PubMed: 21346515PAPER Porta-Etessam J, Tobaruela-González JL, Rabes-Berendes C
Depression in patients with moderate Alzheimer disease: a prospective observational cohort study.
Alzheimer Dis Assoc Disord. 2011 Oct;25(4):317-25. PubMed: 21346516PAPER Rogalski EJ, Rademaker A, Harrison TM, Helenowski I, Johnson N, Bigio E, Mishra M, Weintraub S, Mesulam MM
ApoE E4 is a susceptibility factor in amnestic but not aphasic dementias.
Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):159-63. PubMed: 21346518Philipp Jaeger on Evidence Piles Up for Presenilins’ Role in Autophagy
COMMENT In 2010, Ralph Nixon’s lab published a beautiful study demonstrating the involvement of presenilin-1 (PS1) in autophagy function and lysosome acidification (Lee et al., 2010). They were able to show that certain PS1 mutations, found in familial Alzheimer&
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