330883 RESULTS
THERAPEUTICS 2,4-Thiazolidinedione Takeda Pharmaceutical Company Zinfandel Pharmaceuticals Inc. AD4833 Actos® Glustin™ Piozone® Small Molecule Inflammation Other From 2002 to 2005, a Phase 2 study sponsored by the National Institute on Aging evaluated the safety and t
Other We are pleased to present exclusive short films from “ The Alzheimer’s Project,” sponsored by HBO Documentary Films and the National Institute on Aging of the National Institutes of Health, with support from the Alzheimer’s Association, the Fidelity Chari
MUTATIONS MAPT 44095980 GRCh37/hg19 C T Exon 11 Point, Missense Coding Reduced capacity to bind microtubules. Atrophy of primary motor and premotor cortices; neuronal tau-positive lesions mimicking Pick bodies, especially in the dentate gyrus, and containing aggreg
MUTATIONS MAPT 44073923 GRCh37/hg19 rs63750096 G A Exon 9 Point, Missense Coding Unknown. Found in an individual with tau-negative microvacuolar-type neuropathology attributed to a GRN mutation. A239T Frontotemporal Dementia: BenignFrontotemporal Dementia This vari
RESEARCH MODELS Neuropathology Amyloid plaques by 17-18 months in the neocortex and hippocampus with detection of five to ten-fold more Aβ40 than Aβ42. Plaque burden significantly lower than in the double transgenic PS2APP. Lower levels of insoluble Aβ40 and Aβ42 than th
RESEARCH MODELS Summary These triple transgenic mice express mutant APP, PSEN2, and MAPT. They show age-dependent accumulation of Aβ plaques and neurofibrillary tangle-like pathology, starting around four months of age (Grueninger et al., 2010). Neuropathology Phosphoryl
Iran, Islamic Republic of
Roche CanadaMississauga, Canada
THERAPEUTICS Merck Small Molecule Unknown No information about Phase 1 clinical studies of MK-7622 is available in the public domain. In October 2013, Merck began a Phase 2 trial in the United States to evaluate the compound's tolerability and efficacy as a sympt
PAPER Wischik C, Staff R
Pharmasum TherapeuticsNorway
PAPER Kurtenbach S, Wewering S, Hatt H, Neuhaus EM, Lübbert H
PAPER Henderson-Smith A, Chow D, Meechoovet B, Aziz M, Jacobson SA, Shill HA, Sabbagh MN, Caviness JN, Adler CH, Driver-Dunckley ED, Beach TG, Yin H, Dunckley T
PAPER Zhao X, Zhai S, An MS, Wang YH, Yang YF, Ge HQ, Liu JH, Pu XP
PAPER Zhou Y, Liu S, Liu G, Oztürk A, Hicks GG
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