COMMENT This work establishes that dysregulation of splicing and polyadenylation occur significantly more frequently in C9ORF72 ALS than in sporadic ALS (SALS), with region-specific changes seen in the cerebellum and frontal cortex. Understanding both the ...
German Center for Neurodegenerative Diseases (DZNE)Munich, Germany
New Delhi, India
Newport beach, United States
COMMENT The most striking result of this complex transcriptome analysis was the specificity of C9ORF72-ALS cases to have alterations in the unfolded protein response pathway. It was reassuring to see that many of the genes with altered splicing were the same ALS ...
COMMENT Loss of reelin in embryonic development leads to profound consequences in brain development (such as disrupted cortical layering), making it hard to delineate what impact reelin deficiency has in the adult brain. Therefore, the reelin conditional knockout ...
PAPER Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ
Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.Learn Mem. 2011 Sep;18(9):558-64. Print 2011 Sep PubMed: 21852430
CONFERENCE COVERAGE 2015-08-03 Conference Coverage Ron DeMattos and colleagues at Eli Lilly are challenging the field with extensive studies of combination therapies in mouse models of Alzheimer’s disease. At the Alzheimer's Association International Conference 2015, held July 18 ...
Third Rock VenturesBoston
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