NSE-hPS2(N141I)

RESEARCH MODELS Modification Details Transgene containing human PSEN2 carrying the N141I mutation driven by the neuron-specific enolase (NSE) promoter. Neuropathology Not observed. Cognition/Behavior Behavioral deficits in the water maze at 12 months in mice expressing m

Brexpiprazole

THERAPEUTICS Lundbeck Otsuka Pharmaceutical Co., Ltd. Rexulti OPC 34712 Small Molecule Other Neurotransmitters In July 2013, Otsuka and Lundbeck started a Phase 3 study in the U.S., Europe, and Russia to evaluate brexpiprazole for the treatment of agitation in 560 pat

Russell Blaylock

Theorectical Neuroscience Research, LLC
Ridgeland, United States

PAPER Petitti DB, Crooks VC, Chiu V, Buckwalter JG, Chui HC

Incidence of dementia in long-term hormone users.

Am J Epidemiol. 2008 Mar 15;167(6):692-700. PubMed: 18218608

Emory Bailey

Retired
Cleveland, United States

Craig Shepherd

United States

PAPER Zheng JS, Tang S, Qi YK, Wang ZP, Liu L

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates.

Nat Protoc. 2013 Dec;8(12):2483-95. Epub 2013 Nov 14 PubMed: 24232250

PAPER Takada LT, Geschwind MD

Prion diseases.

Semin Neurol. 2013 Sep;33(4):348-56. Epub 2013 Nov 14 PubMed: 24234356

PAPER Kim TW, Cho HM, Choi SY, Suguira Y, Hayasaka T, Setou M, Koh HC, Hwang EM, Park JY, Kang SJ, Kim HS, Kim H, Sun W

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.

Cell Death Dis. 2013 Nov 14;4:e919. PubMed: 24232095

PAPER Alani B, Salehi R, Sadeghi P, Zare M, Khodagholi F, Arefian E, Hakemi MG, Digaleh H

Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells.

J Mol Neurosci. 2014 Mar;52(3):392-402. PubMed: 24234033

PAPER Flight MH

Neurodegenerative disease: Tau immunotherapy targets transcellular propagation.

Nat Rev Drug Discov. 2013 Dec;12(12):904. Epub 2013 Nov 15 PubMed: 24232374

PAPER Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

J Clin Invest. 2013 Dec 2;123(12):5371-88. Epub 2013 Nov 15 PubMed: 24231356

PAPER Ulbrich L, Cozzolino M, Marini ES, Amori I, De Jaco A, Carrì MT, Augusti-Tocco G

Cystatin B and SOD1: protein–protein interaction and possible relation to neurodegeneration.

Cell Mol Neurobiol. 2014 Mar;34(2):205-13. PubMed: 24234043

PAPER Dupuis JP, Feyder M, Miguelez C, Garcia L, Morin S, Choquet D, Hosy E, Bezard E, Fisone G, Bioulac BH, Baufreton J

Dopamine-dependent long-term depression at subthalamo-nigral synapses is lost in experimental parkinsonism.

J Neurosci. 2013 Sep 4;33(36):14331-41. PubMed: 24005286

PAPER Kim C, Yun N, Lee YM, Jeong JY, Baek JY, Song HY, Ju C, Youdim MB, Jin BK, Kim WK, Oh YJ

Gel-based protease proteomics for identifying the novel calpain substrates in dopaminergic neuronal cell.

J Biol Chem. 2013 Dec 20;288(51):36717-32. Epub 2013 Nov 14 PubMed: 24235151