RESEARCH NEWS 2017-11-22 Research News Homozygous loss-of-function mutations in the microglial receptor TREM2 cause Nasu-Hakola disease, an early onset form of dementia thought to be unrelated to Aβ amyloidosis. Now, researchers led by Laura Ghezzi and Tiziana Carandini at the ...
PAPER Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KP, Hammarström P, Staufenbiel M, Walker LC, Jucker M
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.Proc Natl Acad Sci U S A. 2017 Nov 20; PubMed: 29158413
COMMENT The Wolozin lab furthers the investigation of their original finding that tau complexes with TIA1-positive stress granules (Vanderweyde et al., 2016). In this extension, they show that knocking down TIA1 improves outcomes in P301S mice. The careful and ...
PAPER Bou Samra E, Buhagiar-Labarchède G, Machon C, Guitton J, Onclercq-Delic R, Green MR, Alibert O, Gazin C, Veaute X, Amor-Guéret M
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.Nat Commun. 2017 Sep 25;8(1):693. PubMed: 28947735
PAPER Bryan JB, Nagle BW, Doenges KH1059144
PAPER Papasozomenos SC
Tau protein immunoreactivity in dementia of the Alzheimer type: II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer's abnormal filaments.Lab Invest. 1989 Mar;60(3):375-89. PubMed: 2494388
COMMENT In this new paper, Wolozin and colleagues provide convincing evidence of neuron rescue in the hippocampus and cortices of P301S-tau transgenic mice, upon TIA1 reduction. Cognition and lifespan are also improved. The result that phosphorylated tau is ...
COMMENT This work is a window to expand what we know about the pathophysiology of AD. It is good work and deserves credit. Based on this article and previous findings, I think focus should be directed to: In-depth understanding of inflammation mechanisms. A ...
RESEARCH NEWS 2017-11-22 Research News TIA1 has a toxic relationship with tau. Toxic to neurons, that is. In the November 20 Nature Neuroscience, researchers led by Benjamin Wolozin of Boston University reported that the RNA-binding protein has a penchant for tau oligomers, ...
PAPER Apicco DJ, Ash PE, Maziuk B, LeBlang C, Medalla M, Abdullatif AA, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S S, Cruz AL AL, Kashy D, A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, P, Leszyk J, Hu H, Luebke J, Bryant CD, Wolozin B
COMMENT I am curious to know: How does peripherally injected Aβ penetrate the BBB? Did blood Aβ have any connection with peripheral monocytes and brain microglia? Is the blood Aβ the only factor responsible for detrimental effects on the brain? dhulldinesh ...
PAPER Molteni M, Rossetti C29153601
PAPER Zafeer MF, Firdaus F, Ahmad F, Ullah R, Anis E, Waseem M, Ali A, Hossain MM
Perillyl Alcohol Alleviates Amyloid-β Peptides-Induced mitochondrial dysfunction and Cytotoxicity in SH-SY5Y Cells.Int J Biol Macromol. 2017 Nov 14; PubMed: 29154879
PAPER Seddighi S, Varma VR, An Y, Varma S, Beason-Held LL, Tanaka T, Kitner-Triolo MH, Kraut MA, Davatzikos C, Thambisetty M
SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging.J Alzheimers Dis. 2017 Nov 16; PubMed: 29154276
PAPER Oliveros A, Wininger K, Sens J, Larsson MK, Liu XC, Choi S, Faka A, Schwieler L, Engberg G, Erhardt S, Choi DS
LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning.J Neuroimmunol. 2017 Dec 15;313:1-9. Epub 2017 Sep 28 PubMed: 29153599
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