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Communication Breakdown: Multiple Networks Decline in AD Brains
RESEARCH NEWS 2012-07-11 Research News A healthy brain switches between its different functional networks like a well-oiled machine, but as dementia takes over, communication becomes disorganized. Connections sputter, and once-sharp distinctions between networks blur, according t
For FTD Drug Development, a Q&A With Regulators
CONFERENCE COVERAGE 2012-07-11 Conference Coverage In advance of a 4 June meeting in Washington, D.C., with regulators and industry scientists, Adam Boxer of the University of California, San Francisco, and other steering committee members from the Frontotemporal Degeneration Study Gro
ALS-Linked Ataxin Repeats Stick It to TDP-43 in Stressed Cells
RESEARCH NEWS 2012-07-11 Research News Having a few excess polyglutamine codons—but not a lot—in the gene ataxin-2 predisposes a person to amyotrophic lateral sclerosis, and scientists are just starting to figure out how. In the July 4 Journal of Neuroscience, Michael Hart of the
PAPER Ondo WG
Tetrabenazine treatment for stereotypies and tics associated with dementia.
J Neuropsychiatry Clin Neurosci. 2012 Mar 1;24(2):208-14. PubMed: 22772669PAPER Sai Y, Zou Z, Peng K, Dong Z
The Parkinson's disease-related genes act in mitochondrial homeostasis.
Neurosci Biobehav Rev. 2012 Oct;36(9):2034-43. PubMed: 22771336PAPER Lee HJ, Lee K, Im H
α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.
Biochem Biophys Res Commun. 2012 Aug 3;424(3):497-502. PubMed: 22771809PAPER Tavassoly O, Lee JS
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.
FEBS Lett. 2012 Sep 21;586(19):3222-8. PubMed: 22771474PAPER Kim ST, Doo AR, Kim SN, Kim SY, Kim YY, Kim JH, Lee H, Yin CS, Park HJ
Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus.
J Physiol Sci. 2012 Sep;62(5):377-83. PubMed: 22773088PAPER Spittau B, Zhou X, Ming M, Krieglstein K
IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP(+)-Induced Neurodegeneration.
Neuromolecular Med. 2012 Jul 8; PubMed: 22772723PAPER Appl T, Kaltenbach L, Lo DC, Terstappen GC
Targeting mutant huntingtin for the development of disease-modifying therapy.
Drug Discov Today. 2012 Jul 4; PubMed: 22772050PAPER Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.
Neuropharmacology. 2013 Jan;64:81-96. Epub 2012 Jul 4 PubMed: 22771460PAPER Batailler M, Mullier A, Sidibe A, Delagrange P, Prévot V, Jockers R, Migaud M
Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains.
J Neuroendocrinol. 2012 May;24(5):798-808. PubMed: 22512326PAPER Kiernan MC, Petri S
Hyperexcitability and amyotrophic lateral sclerosis.
Neurology. 2012 May 15;78(20):1544-5. PubMed: 22517105Current Filters
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