PAPER Buckholtz NS
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PAPER Gravitz L
Drugs: a tangled web of targets.
Nature. 2011 Jul 14;475(7355):S9-11. PubMed: 21760583PAPER Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
J Biol Chem. 2011 Sep 23;286(38):33489-500. PubMed: 21795680PAPER Sano M, Bell KL, Galasko D, Galvin JE, Thomas RG, van Dyck CH, Aisen PS
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.
Neurology. 2011 Aug 9;77(6):556-63. PubMed: 21795660PAPER Lamberto GR, Torres-Monserrat V, Bertoncini CW, Salvatella X, Zweckstetter M, Griesinger C, Fernández CO
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.
J Biol Chem. 2011 Sep 16;286(37):32036-44. PubMed: 21795682PAPER Fauser BC, Laven JS, Tarlatzis BC, Moley KH, Critchley HO, Taylor RN, Berga SL, Mermelstein PG, Devroey P, Gianaroli L, D'Hooghe T, Vercellini P, Hummelshoj L, Rubin S, Goverde AJ, De Leo V, Petraglia F
Sex steroid hormones and reproductive disorders: impact on women's health.
Reprod Sci. 2011 Aug;18(8):702-12. PubMed: 21795737PAPER Lee M, Kwon BM, Suk K, McGeer E, McGeer PL
Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage.
J Neuroimmune Pharmacol. 2011 Jul 28; PubMed: 21796424Lary Walker on Neuronal basis of age-related working memory decline.
COMMENT This paper by Wang et al. is well written and makes a strong case for potentially reversible declines in neuronal function with age. As the authors note, despite their relatively close biological proximity to humans, rhesus monkeys do not develop Alzheime
PAPER Radley JJ, Rocher AB, Miller M, Janssen WG, Liston C, Hof PR, McEwen BS, Morrison JH
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex.
Cereb Cortex. 2006 Mar;16(3):313-20. PubMed: 15901656PAPER Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AF
Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals.
Learn Mem. 2006 Nov-Dec;13(6):770-6. PubMed: 17101879PAPER Franowicz JS, Arnsten AF
The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.
Psychopharmacology (Berl). 1998 Mar;136(1):8-14. PubMed: 9537677PAPER Arnsten AF, Cai JX, Goldman-Rakic PS
The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.
J Neurosci. 1988 Nov;8(11):4287-98. PubMed: 2903226PAPER Kruggel F
MRI-based volumetry of head compartments: normative values of healthy adults.
Neuroimage. 2006 Mar;30(1):1-11. PubMed: 16289929PAPER Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D, Arnsten AF
Neuronal basis of age-related working memory decline.
Nature. 2011 Aug 11;476(7359):210-3. PubMed: 21796118PAPER Sherwood CC, Gordon AD, Allen JS, Phillips KA, Erwin JM, Hof PR, Hopkins WD
Aging of the cerebral cortex differs between humans and chimpanzees.
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13029-34. PubMed: 21788499Current Filters
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