COMMENT While there has been a recent flurry of papers investigating CR, biomarkers, and cognition, there is no clear consensus on these interrelationships. The sample characteristics, measures of CR, and cognition appear to greatly influence the picture. However ...
COMMENT This is an interesting article. I do think it is one of a growing number of reports that factors associated with cognitive reserve (CR) may actually directly affect Alzheimer pathology. We also have a previous report (Lo et al., 2013) in which we looked ...
PAPER Perrin S24678540
RESEARCH NEWS 2015-05-05 Research News People with a lot of cognitive reserve generally cope better with advancing dementia, but might they be protected from disease pathology as well? According to a study published April 20 in JAMA Neurology, older adults with at least 16 years ...
PAPER Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VM
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60. PubMed: 8610185
Ligand Pharmaceuticals IncorporatedLa Jolla, United States
RESEARCH MODELS This mouse model is a cross between a well-characterized APP transgenic (APP23) and a PSEN1 knock-in mouse (PS1-R278I) that expresses human PSEN1 with a mutation linked to atypical AD. The R278I mutation alters γ-secretase processing of APP leading to ...
MUTATIONS MAPT Exon 11 Point, Missense Coding Impaired tubulin polymerization. Altered tau aggregation in an isoform-specific manner; accelerated tau assembly in 4R tau while decreasing tau aggregation, misfolding, and filament assembly in 3R tau. Lobar atrophy, ...
Michael Coleman, Jonathan Gilley on Neurobiology. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
COMMENT Progress in science usually comes from considering two apparently contradictory findings and asking how both can be correct. On this occasion there are two such results. One is the striking data reported by Gerdts and colleagues indicating that artificial ...
PAPER Yahata N, Yuasa S, Araki T
Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.J Neurosci. 2009 May 13;29(19):6276-84. PubMed: 19439605
PAPER Shen H, Hyrc KL, Goldberg MP23892229
PAPER Gilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP25818290
PAPER Gilley J, Coleman MP20126265
PAPER Gilley J, Adalbert R, Yu G, Coleman MP23946398
Merck Research LaboratoriesNorth Wales
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